Anti-RCHY1 Antibody (CAB19287)
- SKU:
- CAB19287
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RCHY1
- Synonyms:
- ARNIP
- Synonyms:
- CHIMP
- Synonyms:
- PIRH2
- Synonyms:
- PRO1996
- Synonyms:
- RNF199
- Synonyms:
- ZCHY
- Synonyms:
- ZNF363
- Synonyms:
- ring finger and CHY zinc finger domain containing 1
Description
| Product Name: | RCHY1 Rabbit mAb |
| Product Code: | CAB19287 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RCHY1, ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363, ring finger and CHY zinc finger domain containing 1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human RCHY1. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant protein of human RCHY1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 25898 |
| Uniprot: | Q96PM5 |
| Cellular Location: | Cytoplasm, Nucleus, Nucleus speckle |
| Calculated MW: | 30kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | RCHY1: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and p27Kip1. Preferentially acts on tetrameric p53/TP53. Contributes to the regulation of p27Kip1 and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, p27Kip1, COPE, UBE2D2 and GORAB/NTKLBP1. Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; Nuclear receptor co-regulator; EC 6.3.2.-; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus; ubiquitin ligase complex Molecular Function:protein binding; protein homodimerization activity; zinc ion binding; p53 binding; ubiquitin-protein ligase activity; ligase activity; receptor binding Biological Process: protein autoubiquitination; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination |
| NCBI Summary: | The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q96PM5 |
| NCBI GenInfo Identifier: | 32700008 |
| NCBI Gene ID: | 25898 |
| NCBI Accession: | Q96PM5.1 |
| UniProt Related Accession: | Q96PM5 |
| Molecular Weight: | 30 kDa |
| NCBI Full Name: | RING finger and CHY zinc finger domain-containing protein 1 |
| NCBI Synonym Full Names: | ring finger and CHY zinc finger domain containing 1 |
| NCBI Official Symbol: | RCHY1 |
| NCBI Official Synonym Symbols: | ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996 |
| NCBI Protein Information: | RING finger and CHY zinc finger domain-containing protein 1 |
| UniProt Protein Name: | RING finger and CHY zinc finger domain-containing protein 1 |
| UniProt Synonym Protein Names: | Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2 |
| Protein Family: | RING finger and CHY zinc finger domain-containing protein |
| UniProt Gene Name: | RCHY1 |
| UniProt Entry Name: | ZN363_HUMAN |
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