Anti-RCC1 Antibody (CAB0662)
- SKU:
- CAB0662
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CHC1
- Synonyms:
- RCC1-I
- Synonyms:
- SNHG3-RCC1
- Research Area:
- Cell Cycle
Description
| Product Name: | RCC1 Rabbit mAb |
| Product Code: | CAB0662 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CHC1, RCC1-I, SNHG3-RCC1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RCC1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Raji, SH-SY5Y, Mouse spleen, Mouse thymus, Rat testis |
| Immunogen: | A synthesized peptide derived from human RCC1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1104 |
| Uniprot: | P18754 |
| Calculated MW: | 45kDa |
| Observed MW: | 49kDa |
| UniProt Protein Function: | RCC1: a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Ras; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: nucleoplasm; nuclear membrane; condensed nuclear chromosome; cytoplasm; nuclear chromatin; nucleus Molecular Function:protein binding; nucleosomal DNA binding; Ran guanyl-nucleotide exchange factor activity; histone binding; chromatin binding Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; cell division; regulation of mitosis; spindle assembly; G1/S transition of mitotic cell cycle; chromosome segregation |
| UniProt Code: | P18754 |
| NCBI GenInfo Identifier: | 132170 |
| NCBI Gene ID: | 1104 |
| NCBI Accession: | P18754.1 |
| UniProt Secondary Accession: | P18754,Q16269, Q6NT97, |
| UniProt Related Accession: | P18754 |
| Molecular Weight: | 421 |
| NCBI Full Name: | Regulator of chromosome condensation |
| NCBI Synonym Full Names: | regulator of chromosome condensation 1 |
| NCBI Official Symbol: | RCC1 |
| NCBI Official Synonym Symbols: | CHC1; RCC1-I; SNHG3-RCC1 |
| NCBI Protein Information: | regulator of chromosome condensation; SNHG3-RCC1 readthrough; cell cycle regulatory protein; guanine nucleotide-releasing protein |
| UniProt Protein Name: | Regulator of chromosome condensation |
| UniProt Synonym Protein Names: | Cell cycle regulatory protein; Chromosome condensation protein 1 |
| Protein Family: | RCC1 domain-containing protein |
| UniProt Gene Name: | RCC1 |
| UniProt Entry Name: | RCC1_HUMAN |
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