Cell Biology Antibodies 4
Anti-RBSN Antibody (CAB13792)
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- SKU:
- CAB13792
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RBSN Antibody |
| Antibody SKU: | CAB13792 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RBSN (NP_071735.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RBSN (NP_071735.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASL DDPG EVRE GFLC PLCL KDLQ SFYQ LHSH YEEE HSGE DRDV KGQI KSLV QKAK KAKD RLLK REGD DRAE SGTQ GYES FSYG GVDP YMWE PQEL GAVR SHLS DFKK HRAA RIDH YVVE VNKL IIRL EKLT AFDR TNTE SAKI RAIE KSVV PWVN DQDV PFCP DCGN KFSI RNRR HHCR LCGS IMCK KCME LISL PLAN |
| Gene ID: | 64145 |
| Uniprot: | Q9H1K0 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Early endosome membrane, Lipid-anchor |
| Calculated MW: | 23kDa/88kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RBSN, Rabenosyn-5, ZFYVE20 |
| Background: | This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ZFYVE20: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Adaptor/scaffold Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: early endosome membrane; endosome; endosome membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:protein binding; Rab GTPase binding; zinc ion binding Biological Process: blood coagulation; endocytosis; endosomal vesicle fusion; endosome transport; Golgi to endosome transport; Golgi to vacuole transport; late endosome to vacuole transport; protein transport; vacuole inheritance |
| NCBI Summary: | This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q9H1K0 |
| NCBI GenInfo Identifier: | 108935884 |
| NCBI Gene ID: | 64145 |
| NCBI Accession: | Q9H1K0.2 |
| UniProt Secondary Accession: | Q9H1K0,Q3KP30, Q59EY8, Q8NAQ1, B4DWY8, C9J4P5, |
| UniProt Related Accession: | Q9H1K0 |
| Molecular Weight: | 23,794 Da |
| NCBI Full Name: | Rabenosyn-5 |
| NCBI Synonym Full Names: | rabenosyn, RAB effector |
| NCBI Official Symbol: | RBSN |
| NCBI Official Synonym Symbols: | ZFYVE20; Rabenosyn-5 |
| NCBI Protein Information: | rabenosyn-5 |
| UniProt Protein Name: | Rabenosyn-5 |
| UniProt Synonym Protein Names: | 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN |
| UniProt Gene Name: | RBSN |
| UniProt Entry Name: | RBNS5_HUMAN |
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