Cell Biology Antibodies 4

Anti-RBSN Antibody (CAB13792)

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SKU:
CAB13792
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RBSN Antibody
Antibody SKU:CAB13792
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RBSN (NP_071735.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RBSN (NP_071735.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASL DDPG EVRE GFLC PLCL KDLQ SFYQ LHSH YEEE HSGE DRDV KGQI KSLV QKAK KAKD RLLK REGD DRAE SGTQ GYES FSYG GVDP YMWE PQEL GAVR SHLS DFKK HRAA RIDH YVVE VNKL IIRL EKLT AFDR TNTE SAKI RAIE KSVV PWVN DQDV PFCP DCGN KFSI RNRR HHCR LCGS IMCK KCME LISL PLAN
Gene ID:64145
Uniprot:Q9H1K0
Cellular Location:Cell membrane, Cytoplasmic side, Early endosome membrane, Lipid-anchor
Calculated MW:23kDa/88kDa
Observed MW:Refer to figures
Synonyms:RBSN, Rabenosyn-5, ZFYVE20
Background:This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ZFYVE20: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: early endosome membrane; endosome; endosome membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function:protein binding; Rab GTPase binding; zinc ion binding

Biological Process: blood coagulation; endocytosis; endosomal vesicle fusion; endosome transport; Golgi to endosome transport; Golgi to vacuole transport; late endosome to vacuole transport; protein transport; vacuole inheritance

NCBI Summary:This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Code:Q9H1K0
NCBI GenInfo Identifier:108935884
NCBI Gene ID:64145
NCBI Accession:Q9H1K0.2
UniProt Secondary Accession:Q9H1K0,Q3KP30, Q59EY8, Q8NAQ1, B4DWY8, C9J4P5,
UniProt Related Accession:Q9H1K0
Molecular Weight:23,794 Da
NCBI Full Name:Rabenosyn-5
NCBI Synonym Full Names:rabenosyn, RAB effector
NCBI Official Symbol:RBSN  
NCBI Official Synonym Symbols:ZFYVE20; Rabenosyn-5  
NCBI Protein Information:rabenosyn-5
UniProt Protein Name:Rabenosyn-5
UniProt Synonym Protein Names:110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN
UniProt Gene Name:RBSN  
UniProt Entry Name:RBNS5_HUMAN
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