Anti-RBP4 Antibody (CAB8807)
- SKU:
- CAB8807
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MCOPCB10
- Synonyms:
- RDCCAS
Description
| Product Name: | RBP4 Rabbit mAb |
| Product Code: | CAB8807 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MCOPCB10, RDCCAS |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RBP4 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2 |
| Immunogen: | A synthesized peptide derived from human RBP4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5950 |
| Uniprot: | P02753 |
| Calculated MW: | 23kDa |
| Observed MW: | 22KDa |
| UniProt Protein Function: | Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
| UniProt Protein Details: | Subcellular location: Secreted. Involvement in Disease: Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [ MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Sequence similarities: Belongs to the calycin superfamily. Lipocalin family. Mass spectrometry: Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. Ref.10Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. Ref.12Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. Ref.12 Sequence caution: The sequence AAF69622.1 differs from that shown. Reason: Erroneous initiation. |
| NCBI Summary: | This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq] |
| UniProt Code: | P02753 |
| NCBI GenInfo Identifier: | 62298174 |
| NCBI Gene ID: | 5950 |
| NCBI Accession: | P02753.3 |
| UniProt Secondary Accession: | P02753,O43478, O43479, Q5VY24, Q8WWA3, Q9P178, D3DR38 |
| UniProt Related Accession: | P02753 |
| Molecular Weight: | 23,010 Da |
| NCBI Full Name: | Retinol-binding protein 4 |
| NCBI Synonym Full Names: | retinol binding protein 4, plasma |
| NCBI Official Symbol: | RBP4 |
| NCBI Protein Information: | retinol-binding protein 4; RBP; PRBP; OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; plasma retinol-binding protein; retinol-binding protein 4, interstitial |
| UniProt Protein Name: | Retinol-binding protein 4 |
| UniProt Synonym Protein Names: | Plasma retinol-binding protein |
| Protein Family: | Retinol-binding protein |
| UniProt Gene Name: | RBP4 |
| UniProt Entry Name: | RET4_HUMAN |
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