Signal Transduction Antibodies 2
Anti-RBP4 Antibody (CAB1600)
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- SKU:
- CAB1600
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-RBP4 Antibody |
| Antibody SKU: | CAB1600 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-201 of human RBP4 (NP_006735.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW620, HeLa, OVCAR3, Mouse liver, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-201 of human RBP4 (NP_006735.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ERDC RVSS FRVK ENFD KARF SGTW YAMA KKDP EGLF LQDN IVAE FSVD ETGQ MSAT AKGR VRLL NNWD VCAD MVGT FTDT EDPA KFKM KYWG VASF LQKG NDDH WIVD TDYD TYAV QYSC RLLN LDGT CADS YSFV FSRD PNGL PPEA QKIV RQRQ EELC LARQ YRLI VHNG YCDG RSER NLL |
| Gene ID: | 5950 |
| Uniprot: | P02753 |
| Cellular Location: | Secreted |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
| Synonyms: | RBP4, MCOPCB10, RDCCAS |
| Background: | This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. |
| UniProt Protein Function: | Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
| UniProt Protein Details: | Subcellular location: Secreted. Involvement in Disease: Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [ MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Sequence similarities: Belongs to the calycin superfamily. Lipocalin family. Mass spectrometry: Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. Ref.10Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. Ref.12Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. Ref.12 Sequence caution: The sequence AAF69622.1 differs from that shown. Reason: Erroneous initiation. |
| NCBI Summary: | This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq] |
| UniProt Code: | P02753 |
| NCBI GenInfo Identifier: | 62298174 |
| NCBI Gene ID: | 5950 |
| NCBI Accession: | P02753.3 |
| UniProt Secondary Accession: | P02753,O43478, O43479, Q5VY24, Q8WWA3, Q9P178, D3DR38 |
| UniProt Related Accession: | P02753 |
| Molecular Weight: | 23,010 Da |
| NCBI Full Name: | Retinol-binding protein 4 |
| NCBI Synonym Full Names: | retinol binding protein 4, plasma |
| NCBI Official Symbol: | RBP4 |
| NCBI Protein Information: | retinol-binding protein 4; RBP; PRBP; OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; plasma retinol-binding protein; retinol-binding protein 4, interstitial |
| UniProt Protein Name: | Retinol-binding protein 4 |
| UniProt Synonym Protein Names: | Plasma retinol-binding protein |
| Protein Family: | Retinol-binding protein |
| UniProt Gene Name: | RBP4 |
| UniProt Entry Name: | RET4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RBP4 antibody (CAB1600) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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