Developmental Biology

Anti-RBM45 Antibody (CAB13843)

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SKU:
CAB13843
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-RBM45 Antibody
Antibody SKU:CAB13843
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RBM45 (NP_694453.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain, Mouse heart, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RBM45 (NP_694453.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDEA GSSA SGGG FRPG VDSL DEPP NSRI FLVI SKYT PESV LRER FSPF GDIQ DIWV VRDK HTKE SKGI AFVK FARS SQAC RAME EMHG QCLG PNDT KPIK VFIA QSRS SGSH RDVE DEEL TRIF VMIP KSYT EEDL REKF KVYG DIEY CSII KNKV TGES KGLG YVRY LKPS QAAQ AIEN CDRS FRAI LAEP KNKA SESS EQDY YSNM RQEA LGHE PRVN MFPF EQQS EFSS FDKN DSRG QEAI SKRL SVVS RVPF TEEQ LFSI FDIV PGLE YCEV QRDP YSNY GHGV VQYF NVAS AIYA
Gene ID:129831
Uniprot:Q8IUH3
Cellular Location:Cytoplasm, Nucleus
Calculated MW:37kDa/53kDa
Observed MW:52-54kDa
Synonyms:RBM45, DRB1, RB-1
Background:This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8.
UniProt Protein Function:DRBP1: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; RNA binding

Biological Process: nervous system development

NCBI Summary:This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]
UniProt Code:Q8IUH3
NCBI GenInfo Identifier:59797947
NCBI Gene ID:129831
NCBI Accession:Q8IUH3.1
UniProt Secondary Accession:Q8IUH3,Q6NYL0, Q8NFC9,
UniProt Related Accession:Q8IUH3
Molecular Weight:53,346 Da
NCBI Full Name:RNA-binding protein 45
NCBI Synonym Full Names:RNA binding motif protein 45
NCBI Official Symbol:RBM45  
NCBI Official Synonym Symbols:DRB1; RB-1  
NCBI Protein Information:RNA-binding protein 45
UniProt Protein Name:RNA-binding protein 45
UniProt Synonym Protein Names:Developmentally-regulated RNA-binding protein 1; RB-1; RNA-binding motif protein 45
Protein Family:RNA-binding protein
UniProt Gene Name:RBM45  
UniProt Entry Name:RBM45_HUMAN
Anti-RBM45 Antibody (CAB13843)Western blot analysis of extracts of various cell lines, using RBM45 antibody (CAB13843) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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