Epigenetics & Nuclear Signaling Antibodies 1
Anti-RBM22 Antibody (CAB10025)
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- SKU:
- CAB10025
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-RBM22 Antibody |
| Antibody SKU: | CAB10025 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBM22 (NP_060517.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, MCF7, K-562, SH-SY5Y, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBM22 (NP_060517.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATS LGSN TYNR QNWE DADF PILC QTCL GENP YIRM TKEK YGKE CKIC ARPF TVFR WCPG VRMR FKKT EVCQ TCSK LKNV CQTC LLDL EYGL PIQV RDAG LSFK DDMP KSDV NKEY YTQN MERE ISNS DGTR PVGM LGKA TSTS DMLL KLAR TTPY YKRN RPHI CSFW VKGE CKRG EECP YRHE KPTD PDDP LADQ NIKD RYYG INDP VADK LLKR ASTM PRLD PPED KT |
| Gene ID: | 55696 |
| Uniprot: | Q9NW64 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | RBM22, Cwc2, ZC3H16, fSAP47 |
| Background: | This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. |
| UniProt Protein Function: | RBM22: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Belongs to the SLT11 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 5q33.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:calcium-dependent protein binding; nucleocytoplasmic transporter activity; protein binding; U6 snRNA binding Biological Process: nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of RNA splicing; protein import into nucleus, translocation; spliceosomal snRNP biogenesis |
| NCBI Summary: | This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9NW64 |
| NCBI GenInfo Identifier: | 74762758 |
| NCBI Gene ID: | 55696 |
| NCBI Accession: | Q9NW64.1 |
| UniProt Secondary Accession: | Q9NW64,O95607, A6NDM5, B4DLI9, |
| UniProt Related Accession: | Q9NW64 |
| Molecular Weight: | 41,152 Da |
| NCBI Full Name: | Pre-mRNA-splicing factor RBM22 |
| NCBI Synonym Full Names: | RNA binding motif protein 22 |
| NCBI Official Symbol: | RBM22 |
| NCBI Official Synonym Symbols: | Cwc2; ZC3H16; fSAP47 |
| NCBI Protein Information: | pre-mRNA-splicing factor RBM22 |
| UniProt Protein Name: | Pre-mRNA-splicing factor RBM22 |
| UniProt Synonym Protein Names: | RNA-binding motif protein 22; Zinc finger CCCH domain-containing protein 16 |
| Protein Family: | Pre-mRNA-splicing factor |
| UniProt Gene Name: | RBM22 |
| UniProt Entry Name: | RBM22_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RBM22 antibody (CAB10025) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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