Immunology Antibodies 2
Anti-RBM15 Antibody (CAB4936)
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- SKU:
- CAB4936
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RBM15
- Synonyms:
- OTT
- Synonyms:
- OTT1
- Synonyms:
- SPEN
- Research Area:
- Immunology
Description
| Product Name: | RBM15 Rabbit pAb |
| Product Code: | CAB4936 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RBM15, OTT, OTT1, SPEN |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HL-60, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EHRY QQQY LQPL PLTH YELV TDAF GHRA PDPL RGAR DRTP PLLY RDRD RDLY PDSD WVPP PPPV RERS TRTA ATSV PAYE PLDS LDRR RDGW SLDR DRGD RDLP SSRD QPRK RRLP EESG GRHL DRSP ESDR PRKR HCAP SPDR SPEL SSSR DRYN SDND RSSR LLLE RPSP IRDR RGSL EKSQ GDKR DRKN SASA ERDR KHRT TAPT EGKS PLKK EDRS DGSA PSTS TASS KLKS PSQK QDGG TAPV ASA |
| Gene ID: | 64783 |
| Uniprot: | Q96T37 |
| Cellular Location: | Nucleus, Nucleus membrane, Nucleus speckle, Peripheral membrane protein, nucleoplasm |
| Calculated MW: | 99kDa/104kDa/106kDa/107kDa |
| Observed MW: | 120kDa |
| UniProt Protein Function: | RBM15: May be implicated in HOX gene regulation. A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Belongs to the RRM Spen family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Oncoprotein; RNA-binding Chromosomal Location of Human Ortholog: 1p13 Cellular Component: nucleoplasm; nuclear membrane Molecular Function:protein binding; nucleotide binding Biological Process: spleen development; patterning of blood vessels; negative regulation of myeloid cell differentiation; viral reproduction; negative regulation of transcription, DNA-dependent; activation of Notch receptor target transcription factor |
| NCBI Summary: | Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009] |
| UniProt Code: | Q96T37 |
| NCBI GenInfo Identifier: | 32363506 |
| NCBI Gene ID: | 64783 |
| NCBI Accession: | Q96T37.2 |
| UniProt Secondary Accession: | Q96T37,Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4 Q96SC5, Q96SC6, Q96SC9, Q96SD0, A1A693, |
| UniProt Related Accession: | Q96T37 |
| Molecular Weight: | 977 |
| NCBI Full Name: | Putative RNA-binding protein 15 |
| NCBI Synonym Full Names: | RNA binding motif protein 15 |
| NCBI Official Symbol: | RBM15 |
| NCBI Official Synonym Symbols: | OTT; OTT1; SPEN |
| NCBI Protein Information: | putative RNA-binding protein 15; one twenty-two; one twenty two protein; one-twenty two protein 1; RNA-binding motif protein 15 |
| UniProt Protein Name: | Putative RNA-binding protein 15 |
| UniProt Synonym Protein Names: | One-twenty two protein 1; RNA-binding motif protein 15 |
| Protein Family: | Putative RNA-binding protein |
| UniProt Gene Name: | RBM15 |
| UniProt Entry Name: | RBM15_HUMAN |
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