Immunology Antibodies 2

Anti-RBM15 Antibody (CAB4936)

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SKU:
CAB4936
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RBM15
Synonyms:
OTT
Synonyms:
OTT1
Synonyms:
SPEN
Research Area:
Immunology

Description

Product Name:RBM15 Rabbit pAb
Product Code:CAB4936
Size:20uL, 50uL, 100uL
Synonyms:RBM15, OTT, OTT1, SPEN
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HL-60, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EHRY QQQY LQPL PLTH YELV TDAF GHRA PDPL RGAR DRTP PLLY RDRD RDLY PDSD WVPP PPPV RERS TRTA ATSV PAYE PLDS LDRR RDGW SLDR DRGD RDLP SSRD QPRK RRLP EESG GRHL DRSP ESDR PRKR HCAP SPDR SPEL SSSR DRYN SDND RSSR LLLE RPSP IRDR RGSL EKSQ GDKR DRKN SASA ERDR KHRT TAPT EGKS PLKK EDRS DGSA PSTS TASS KLKS PSQK QDGG TAPV ASA
Gene ID:64783
Uniprot:Q96T37
Cellular Location:Nucleus, Nucleus membrane, Nucleus speckle, Peripheral membrane protein, nucleoplasm
Calculated MW:99kDa/104kDa/106kDa/107kDa
Observed MW:120kDa
UniProt Protein Function:RBM15: May be implicated in HOX gene regulation. A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Belongs to the RRM Spen family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Spliceosome; Oncoprotein; RNA-binding

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: nucleoplasm; nuclear membrane

Molecular Function:protein binding; nucleotide binding

Biological Process: spleen development; patterning of blood vessels; negative regulation of myeloid cell differentiation; viral reproduction; negative regulation of transcription, DNA-dependent; activation of Notch receptor target transcription factor

NCBI Summary:Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
UniProt Code:Q96T37
NCBI GenInfo Identifier:32363506
NCBI Gene ID:64783
NCBI Accession:Q96T37.2
UniProt Secondary Accession:Q96T37,Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4 Q96SC5, Q96SC6, Q96SC9, Q96SD0, A1A693,
UniProt Related Accession:Q96T37
Molecular Weight:977
NCBI Full Name:Putative RNA-binding protein 15
NCBI Synonym Full Names:RNA binding motif protein 15
NCBI Official Symbol:RBM15  
NCBI Official Synonym Symbols:OTT; OTT1; SPEN  
NCBI Protein Information:putative RNA-binding protein 15; one twenty-two; one twenty two protein; one-twenty two protein 1; RNA-binding motif protein 15
UniProt Protein Name:Putative RNA-binding protein 15
UniProt Synonym Protein Names:One-twenty two protein 1; RNA-binding motif protein 15
Protein Family:Putative RNA-binding protein
UniProt Gene Name:RBM15  
UniProt Entry Name:RBM15_HUMAN
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