Cell Cycle Antibodies 1
Anti-RBL2 Antibody (CAB13649)
- SKU:
- CAB13649
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Antibody Name: | Anti-RBL2 Antibody |
Antibody SKU: | CAB13649 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL2 (NP_005602.3). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL2 (NP_005602.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | PTVS KGTV EGNY VSLT RILK CSEQ SLIE FFNK MKKW EDMA NLPP HFRE RTER LERN FTVS AVIF KKYE PIFQ DIFK YPQE EQPR QQRG RKQR RQPC TVSE I |
Gene ID: | 5934 |
Uniprot: | Q08999 |
Cellular Location: | Nucleus |
Calculated MW: | 59kDa/128kDa |
Observed MW: | Refer to Figures |
Synonyms: | RBL2, P130, Rb2 |
Background: |
UniProt Protein Function: | Rb-like 2: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. |
UniProt Protein Details: | Protein type:Tumor suppressor; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; DNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of cell cycle; regulation of lipid kinase activity; chromatin modification; mitotic cell cycle |
UniProt Code: | Q08999 |
NCBI GenInfo Identifier: | 116242746 |
NCBI Gene ID: | 5934 |
NCBI Accession: | Q08999.3 |
UniProt Secondary Accession: | Q08999,Q15073, Q16084, Q8NE70, Q92812, B7Z913, |
UniProt Related Accession: | Q08999 |
Molecular Weight: | 59,349 Da |
NCBI Full Name: | Retinoblastoma-like protein 2 |
NCBI Synonym Full Names: | retinoblastoma-like 2 |
NCBI Official Symbol: | RBL2 |
NCBI Official Synonym Symbols: | Rb2; P130 |
NCBI Protein Information: | retinoblastoma-like protein 2; PRB2; RBR-2; retinoblastoma-related protein 2; 130 kDa retinoblastoma-associated protein |
UniProt Protein Name: | Retinoblastoma-like protein 2 |
UniProt Synonym Protein Names: | 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2 |
Protein Family: | RHOMBOID-like protein |
UniProt Gene Name: | RBL2 |
UniProt Entry Name: | RBL2_HUMAN |
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