Anti-RBL1 Antibody (CAB20518)
- SKU:
- CAB20518
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PRB1
- Synonyms:
- p107
- Synonyms:
- CP107
Description
| Product Name: | RBL1 Rabbit pAb |
| Product Code: | CAB20518 |
| Size: | 50uL, 100uL |
| Synonyms: | PRB1, p107, CP107 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL1 (NP_002886.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, HT-29 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL1 (NP_002886.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5933 |
| Uniprot: | P28749 |
| Calculated MW: | 120kDa |
| Observed MW: | 115kDa |
| UniProt Protein Function: | Rb-like 1: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function:protein binding; transcription factor binding Biological Process: transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; regulation of cell cycle; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; chromatin modification; mitotic cell cycle; regulation of lipid kinase activity; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28749 |
| NCBI GenInfo Identifier: | 90103515 |
| NCBI Gene ID: | 5933 |
| NCBI Accession: | P28749.3 |
| UniProt Secondary Accession: | P28749,Q4VXA0, Q8N5K6, Q9H1L5, Q9H1M1, A8K2W5, |
| UniProt Related Accession: | P28749 |
| Molecular Weight: | 114,688 Da |
| NCBI Full Name: | Retinoblastoma-like protein 1 |
| NCBI Synonym Full Names: | retinoblastoma-like 1 |
| NCBI Official Symbol: | RBL1 |
| NCBI Official Synonym Symbols: | PRB1; p107; CP107 |
| NCBI Protein Information: | retinoblastoma-like protein 1; cellular protein 107; retinoblastoma-like 1 (p107); 107 kDa retinoblastoma-associated protein |
| UniProt Protein Name: | Retinoblastoma-like protein 1 |
| UniProt Synonym Protein Names: | 107 kDa retinoblastoma-associated protein; p107; pRb1 |
| Protein Family: | RHOMBOID-like protein |
| UniProt Gene Name: | RBL1 |
| UniProt Entry Name: | RBL1_HUMAN |
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