Anti-RBCK1 Antibody (CAB20468)

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SKU:
CAB20468

Description

Product Name:RBCK1 Rabbit pAb
Product Code:CAB20468
Size:50uL, 100uL
Synonyms:XAP3, XAP4, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, HOIL-1, ZRANB4, C20orf18, UBCE7IP3
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RBCK1.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse lung, Rat lung
Immunogen:Recombinant protein of human RBCK1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10616
Uniprot:Q9BYM8
Calculated MW:57kDa
Observed MW:58kDa
UniProt Protein Function:RBCK1: a E3 ubiquitin-protein ligase that contains a zf-RanBP (Zn-finger in Ran binding protein) and a zf-C3HC4 (RING finger) domain. Phosphorylation apparently reduces its E3 activity. Functions as a transcriptional activator. Its nuclear translocation is prevented by binding to a splice-variant of RBCK1 that lacks the RING finger domain. Interacts with PKCB1, PKCZ, and accepts ubiquitin from E2 ubiquitin-conjugating enzymes including UBE2L3. Interacts with PKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Three splice-variant isoforms of the human protein have been reported. Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytosol Molecular Function: protein binding; ubiquitin binding; ubiquitin-protein ligase activity Biological Process: activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; T cell receptor signaling pathway Disease: Polyglucosan Body Myopathy, Early-onset, With Or Without Immunodeficiency
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYM8
NCBI GenInfo Identifier:166214993
NCBI Gene ID:10616
NCBI Accession:Q9BYM8.2
UniProt Secondary Accession:Q9BYM8,O95623, Q86SL2, Q96BS3, Q9BYM9
UniProt Related Accession:Q9BYM8
Molecular Weight:25,654 Da
NCBI Full Name:RanBP-type and C3HC4-type zinc finger-containing protein 1
NCBI Synonym Full Names:RANBP2-type and C3HC4-type zinc finger containing 1
NCBI Official Symbol:RBCK1  
NCBI Official Synonym Symbols:XAP3; XAP4; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; HOIL-1; ZRANB4; C20orf18; UBCE7IP3  
NCBI Protein Information:ranBP-type and C3HC4-type zinc finger-containing protein 1
UniProt Protein Name:RanBP-type and C3HC4-type zinc finger-containing protein 1
UniProt Synonym Protein Names:HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; Hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1Curated; Ubiquitin-conjugating enzyme 7-interacting protein 3
Protein Family:
UniProt Gene Name:RBCK1  
UniProt Entry Name:
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
XAP3
Synonyms:
XAP4
Synonyms:
HOIL1
Synonyms:
PBMEI
Synonyms:
PGBM1
Synonyms:
RBCK2
Synonyms:
RNF54
Synonyms:
HOIL-1
Synonyms:
ZRANB4
Synonyms:
C20orf18
Synonyms:
UBCE7IP3
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