Name: Anti-RBBP6 Antibody (CAB6966)
Brand: Epigenetics & Nuclear Signaling Antibodies 4
SKU: CAB6966
Availability: OutOfStock

Antibody Name:	Anti-RBBP6 Antibody
Antibody SKU:	CAB6966
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RBBP6 (NP_116015.2).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:	HL-60, Jurkat

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RBBP6 (NP_116015.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSCV HYKF SSKL NYDT VTFD GLHI SLCD LKKQ IMGR EKLK AADC DLQI TNAQ TKEE YTDD NALI PKNS SVIV RRIP IGGV KSTS KTYV ISRT EPAM ATTK AVCK NTIS HFFY TLLL PL
Gene ID:	5930
Uniprot:	Q7Z6E9
Cellular Location:	Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus
Calculated MW:	13kDa/106kDa/197kDa/201kDa
Observed MW:	160kDa

Synonyms:

RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA

Background:

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

UniProt Protein Function:	RBBP6: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cell cycle regulation; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Nucleolus; Ubiquitin ligase Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; chromosome Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: in utero embryonic development; multicellular organism growth; protein ubiquitination during ubiquitin-dependent protein catabolic process; embryonic organ development
NCBI Summary:	The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q7Z6E9
NCBI GenInfo Identifier:	74762440
NCBI Gene ID:	5930
NCBI Accession:	Q7Z6E9.1
UniProt Secondary Accession:	Q7Z6E9,Q147T5, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8 Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4,
UniProt Related Accession:	Q7Z6E9
Molecular Weight:	1792
NCBI Full Name:	E3 ubiquitin-protein ligase RBBP6
NCBI Synonym Full Names:	retinoblastoma binding protein 6
NCBI Official Symbol:	RBBP6
NCBI Official Synonym Symbols:	PACT; MY038; P2P-R; RBQ-1; SNAMA
NCBI Protein Information:	E3 ubiquitin-protein ligase RBBP6; protein P2P-R; RB-binding Q-protein 1; retinoblastoma-binding Q protein 1; proliferation potential-related protein; p53-associated cellular protein of testis; retinoblastoma-binding protein 6, isoform 3
UniProt Protein Name:	E3 ubiquitin-protein ligase RBBP6
UniProt Synonym Protein Names:	Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis
Protein Family:	E3 ubiquitin-protein ligase
UniProt Gene Name:	RBBP6
UniProt Entry Name:	RBBP6_HUMAN