Cell Death Antibodies 2
Anti-RASSF6 Antibody (CAB5187)
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- SKU:
- CAB5187
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-RASSF6 Antibody |
| Antibody SKU: | CAB5187 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse intestine, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTMM AHQY PSWI FINE KTFI TREQ LNSL LKTY NIFY ENQK NLHI LYGE TEDG KLIV EGML DIFW GVKR PIQL KIQD EKPF SSFT SMKS SDVF SSKG MTRW GEFD DLYR ISEL DRTQ IPMS EKRN SQED YLSY HSNT LKPH AKDE PDSP VLYR TMSE AALV RKRM KPLM MDRK ERQK NRAS INGH FYNH EIEN SPQD FALH IIFA TGEQ RRLK KTDI PLLQ RLLQ GPSE KNAR IFLM DKDA EEIS SDVA QYIN FHFS LLES ILQR LNEE EKRE IQRI VTKF NKEK AIIL KCLQ NKLV IKTE TTV |
| Gene ID: | 166824 |
| Uniprot: | Q6ZTQ3 |
| Cellular Location: | |
| Calculated MW: | 35kDa/37kDa/39kDa/43kDa |
| Observed MW: | 54kDa |
| Synonyms: | RASSF6 |
| Background: | This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. |
| UniProt Protein Function: | RASSF6: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q13.3 Molecular Function:protein binding Biological Process: apoptosis; positive regulation of apoptosis; signal transduction |
| NCBI Summary: | This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q6ZTQ3 |
| NCBI GenInfo Identifier: | 74749658 |
| NCBI Gene ID: | 166824 |
| NCBI Accession: | Q6ZTQ3.1 |
| UniProt Secondary Accession: | Q6ZTQ3,Q68DT2, Q6PDA6, Q86WG9, Q86WH0, |
| UniProt Related Accession: | Q6ZTQ3 |
| Molecular Weight: | 369 |
| NCBI Full Name: | Ras association domain-containing protein 6 |
| NCBI Synonym Full Names: | Ras association (RalGDS/AF-6) domain family member 6 |
| NCBI Official Symbol: | RASSF6 |
| NCBI Protein Information: | ras association domain-containing protein 6; putative RAS binding protein; Ras association (RalGDS/AF-6) domain family 6 |
| UniProt Protein Name: | Ras association domain-containing protein 6 |
| Protein Family: | Ras association domain-containing protein |
| UniProt Gene Name: | RASSF6 |
| UniProt Entry Name: | RASF6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RASSF6 antibody (CAB5187) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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