Cell Cycle Antibodies 1
Anti-RASSF2 Antibody (CAB15767)
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- SKU:
- CAB15767
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-RASSF2 Antibody |
| Antibody SKU: | CAB15767 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-160 of human RASSF2 (NP_055552.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-160 of human RASSF2 (NP_055552.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQDD NERI RPPP SSSS WHSG CNLG AQGT TLKP LTVP KVQI SEVD APPE GDQM PSST DSRG LKPL QEDT PQLM RTRS DVGV RRRG NVRT PSD |
| Gene ID: | 9770 |
| Uniprot: | P50749 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 17kDa/37kDa |
| Observed MW: | 38kDa |
| Synonyms: | RASSF2, CENP-34, RASFADIN |
| Background: | This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. |
| UniProt Protein Function: | RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Tumor suppressor Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytoplasm; nucleus; protein complex Molecular Function:protein binding; protein kinase activity Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase activity; protein stabilization |
| NCBI Summary: | This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50749 |
| NCBI GenInfo Identifier: | 1723118 |
| NCBI Gene ID: | 9770 |
| NCBI Accession: | P50749.1 |
| UniProt Secondary Accession: | P50749,Q17S06, Q53HD0, Q6AHZ2, Q8IZA5, A6NIX9, A8K5Z3 |
| UniProt Related Accession: | P50749 |
| Molecular Weight: | 17,879 Da |
| NCBI Full Name: | Ras association domain-containing protein 2 |
| NCBI Synonym Full Names: | Ras association domain family member 2 |
| NCBI Official Symbol: | RASSF2 |
| NCBI Official Synonym Symbols: | CENP-34; RASFADIN |
| NCBI Protein Information: | ras association domain-containing protein 2 |
| UniProt Protein Name: | Ras association domain-containing protein 2 |
| Protein Family: | Ras association domain-containing protein |
| UniProt Gene Name: | RASSF2 |
| UniProt Entry Name: | RASF2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RASSF2 antibody (CAB15767) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s. |
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