Cell Cycle Antibodies 1

Anti-RASSF2 Antibody (CAB15766)

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SKU:
CAB15766
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-RASSF2 Antibody
Antibody SKU:CAB15766
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-160 of human RASSF2 (NP_055552.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-160 of human RASSF2 (NP_055552.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQDD NERI RPPP SSSS WHSG CNLG AQGT TLKP LTVP KVQI SEVD APPE GDQM PSST DSRG LKPL QEDT PQLM RTRS DVGV RRRG NVRT PSD
Gene ID:9770
Uniprot:P50749
Cellular Location:Cytoplasm, Nucleus
Calculated MW:17kDa/37kDa
Observed MW:37kDa
Synonyms:RASSF2, CENP-34, RASFADIN
Background:This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.
UniProt Protein Function:RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
UniProt Protein Details:

Protein type:Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; nucleus; protein complex

Molecular Function:protein binding; protein kinase activity

Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase activity; protein stabilization

NCBI Summary:This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P50749
NCBI GenInfo Identifier:1723118
NCBI Gene ID:9770
NCBI Accession:P50749.1
UniProt Secondary Accession:P50749,Q17S06, Q53HD0, Q6AHZ2, Q8IZA5, A6NIX9, A8K5Z3
UniProt Related Accession:P50749
Molecular Weight:17,879 Da
NCBI Full Name:Ras association domain-containing protein 2
NCBI Synonym Full Names:Ras association domain family member 2
NCBI Official Symbol:RASSF2  
NCBI Official Synonym Symbols:CENP-34; RASFADIN  
NCBI Protein Information:ras association domain-containing protein 2
UniProt Protein Name:Ras association domain-containing protein 2
Protein Family:Ras association domain-containing protein
UniProt Gene Name:RASSF2  
UniProt Entry Name:RASF2_HUMAN
Anti-RASSF2 Antibody (CAB15766)Western blot analysis of extracts of Raji cells, using RASSF2 antibody (CAB15766) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s.
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