Cell Biology Antibodies 11
Anti-RASGRP3 Antibody (CAB7791)
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- SKU:
- CAB7791
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RASGRP3 Antibody |
| Antibody SKU: | CAB7791 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-689 of human RASGRP3 (NP_056191.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, A-549, Mouse heart, Mouse lung, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-689 of human RASGRP3 (NP_056191.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLAC RRFA RAPS LSSG HGSL PGSP SLPP AQDE VFEF PGVT AGHR DLDS RAIT LVTG SSRK ISVR LQRA TTSQ ATQT EPVW SEAG WGDS GSHT FPKM KSKF HDKA AKDK GFAK WENE KPRV HAGV DVVD RGTE FELD QDEG EETR QDGE DG |
| Gene ID: | 25780 |
| Uniprot: | Q8IV61 |
| Cellular Location: | |
| Calculated MW: | 78kDa |
| Observed MW: | 78kDa |
| Synonyms: | RASGRP3, GRP3 |
| Background: | The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. |
| UniProt Protein Function: | Guanine nucleotide exchange factor (GEF) for Ras and Rap1. |
| NCBI Summary: | The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] |
| UniProt Code: | Q8IV61 |
| NCBI GenInfo Identifier: | 213385270 |
| NCBI Gene ID: | 25780 |
| NCBI Accession: | NP_001132960.1 |
| UniProt Secondary Accession: | Q8IV61,O94931, Q53SD7, D6W583, |
| UniProt Related Accession: | Q8IV61 |
| Molecular Weight: | 75 |
| NCBI Full Name: | ras guanyl-releasing protein 3 isoform 1 |
| NCBI Synonym Full Names: | RAS guanyl releasing protein 3 |
| NCBI Official Symbol: | RASGRP3 |
| NCBI Official Synonym Symbols: | GRP3 |
| NCBI Protein Information: | ras guanyl-releasing protein 3 |
| UniProt Protein Name: | Ras guanyl-releasing protein 3 |
| UniProt Synonym Protein Names: | Calcium and DAG-regulated guanine nucleotide exchange factor III; Guanine nucleotide exchange factor for Rap1 |
| Protein Family: | Glycine-rich protein |
| UniProt Gene Name: | RASGRP3 |
 | Western blot analysis of extracts of various cell lines, using RASGRP3 antibody (CAB7791) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using RASGRP3 antibody (CAB7791) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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