Cell Biology Antibodies 7

Anti-RASD2 Antibody (CAB17367)

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SKU:
CAB17367
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RASD2 Antibody
Antibody SKU:CAB17367
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human RASD2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human RASD2.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23551
Uniprot:Q96D21
Cellular Location:
Calculated MW:30kDa
Observed MW:Refer to figures
Synonyms:Rhes, TEM2, MGC:4834, RASD2
Background:This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.
UniProt Protein Function:RASD2: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Belongs to the small GTPase superfamily. RasD family.
UniProt Protein Details:

Protein type:G protein, monomeric, RasD; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: plasma membrane

Molecular Function:GTPase activity; GTP binding; ubiquitin conjugating enzyme binding; G-protein beta-subunit binding

Biological Process: positive regulation of protein sumoylation; synaptic transmission, dopaminergic; positive regulation of protein kinase B signaling cascade; metabolic process; small GTPase mediated signal transduction; locomotory behavior; negative regulation of protein ubiquitination

NCBI Summary:This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq, Jul 2008]
UniProt Code:Q96D21
NCBI GenInfo Identifier:21362868
NCBI Gene ID:23551
NCBI Accession:Q96D21.1
UniProt Secondary Accession:Q96D21,O95520, Q5THY8,
UniProt Related Accession:Q96D21
Molecular Weight:30,366 Da
NCBI Full Name:GTP-binding protein Rhes
NCBI Synonym Full Names:RASD family, member 2
NCBI Official Symbol:RASD2  
NCBI Official Synonym Symbols:Rhes; TEM2; MGC:4834  
NCBI Protein Information:GTP-binding protein Rhes; tumor endothelial marker 2; Ras homolog enriched in striatum
UniProt Protein Name:GTP-binding protein Rhes
UniProt Synonym Protein Names:Ras homolog enriched in striatum; Tumor endothelial marker 2
Protein Family:GTP-binding protein
UniProt Gene Name:RASD2  
UniProt Entry Name:RHES_HUMAN
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