Cell Biology Antibodies 5

Anti-RASAL2 Antibody (CAB15120)

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SKU:
CAB15120
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RASAL2 Antibody
Antibody SKU:CAB15120
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-1040 of human RASAL2 (NP_733793.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-1040 of human RASAL2 (NP_733793.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LADI TKSL TNPT PIQQ QLRR FTEH NSSP NVSG SLSS GLQK IFED PTDS DLHK LKSP SQDN TDSY FRGK TLLL VQQA SSQS MTYS EKDE RESS LPNG RSVS LMDL QDTH AAQV EHAS VMLD VPIR LTGS QLSI TQVA SIKQ LRET QSTP QSAP QVRR PLHP ALNQ PGGL QPLS FQNP VYHL NNPI PAMP KASI DSSL ENLS TASS RSQS NSED FKLS GPSN SSME DFTK RSTQ SEDF SRRH TVPD RHIP LALP RQNS TGQA QIRK VDQG GLGA RAKA PPSL PHSA SLRS TGS
Gene ID:9462
Uniprot:Q9UJF2
Cellular Location:
Calculated MW:128kDa/143kDa
Observed MW:160kDa
Synonyms:RASAL2, NGAP
Background:This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
UniProt Protein Function:RASAL2: Inhibitory regulator of the Ras-cyclic AMP pathway.
UniProt Protein Details:

Protein type:GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: cytoplasm; cytosol

Molecular Function:protein binding

Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction

NCBI Summary:This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UJF2
NCBI GenInfo Identifier:13959419
NCBI Gene ID:9462
NCBI Accession:Q9UJF2.2
UniProt Secondary Accession:Q9UJF2,O95174, Q2TB22, Q5TFU9, F8W755,
UniProt Related Accession:Q9UJF2
Molecular Weight:143,899 Da
NCBI Full Name:Ras GTPase-activating protein nGAP
NCBI Synonym Full Names:RAS protein activator like 2
NCBI Official Symbol:RASAL2  
NCBI Official Synonym Symbols:NGAP  
NCBI Protein Information:ras GTPase-activating protein nGAP
UniProt Protein Name:Ras GTPase-activating protein nGAP
UniProt Synonym Protein Names:RAS protein activator-like 2
Protein Family:Ras GTPase-activating protein
UniProt Gene Name:RASAL2  
UniProt Entry Name:NGAP_HUMAN
Anti-RASAL2 Antibody (CAB15120)Western blot analysis of extracts of HeLa cells, using RASAL2 antibody (CAB15120) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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