Name: Anti-Ras Antibody (CAB4735)
Brand: Cell Biology Antibodies 15
SKU: CAB4735
Availability: OutOfStock

Antibody Name:	Anti-Ras Antibody
Antibody SKU:	CAB4735
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human Ras

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, A-549, SH-SY5Y, Mouse testis, Mouse brain, Mouse spleen, Rat lung

Immunogen:	A synthesized peptide derived from human Ras
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	4893
Uniprot:	P01111/P01112/P01116_
Cellular Location:
Calculated MW:	18kDa
Observed MW:	20KDa

Synonyms:

ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6

Background:

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

UniProt Protein Function:	NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: Golgi apparatus; membrane; plasma membrane Molecular Function:protein complex binding Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular
NCBI Summary:	This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
UniProt Code:	P01111
NCBI GenInfo Identifier:	131883
NCBI Gene ID:	4893
NCBI Accession:	P01111.1
UniProt Secondary Accession:	P01111,Q14971, Q15104, Q15282,
UniProt Related Accession:	P01111
Molecular Weight:	21,229 Da
NCBI Full Name:	GTPase NRas
NCBI Synonym Full Names:	neuroblastoma RAS viral oncogene homolog
NCBI Official Symbol:	NRAS
NCBI Official Synonym Symbols:	NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
NCBI Protein Information:	GTPase NRas
UniProt Protein Name:	GTPase NRas
UniProt Synonym Protein Names:	Transforming protein N-Ras
Protein Family:	GTPase
UniProt Gene Name:	NRAS
UniProt Entry Name:	RASN_HUMAN