Metabolism Antibodies 3

Anti-RARRES3 Antibody (CAB8784)

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SKU:
CAB8784
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-RARRES3 Antibody
Antibody SKU:CAB8784
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human RARRES3 (NP_004576.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human RARRES3 (NP_004576.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASP HQEP KPGD LIEI FRLG YEHW ALYI GDGY VIHL APPS EYPG AGSS SVFS VLSN SAEV KRER LEDV VGGC CYRV NNSL DHEY QPRP VEVI ISSA KEMV GQKM KYSI VSRN CEHF VTQL RYGK SRCK QVEK AKV
Gene ID:5920
Uniprot:Q9UL19
Cellular Location:Membrane, Single-pass membrane protein
Calculated MW:17kDa/18kDa
Observed MW:18kDa
Synonyms:RARRES3, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3
Background:Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.
UniProt Protein Function:RARRES3: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Belongs to the H-rev107 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 11q23

Molecular Function:phospholipase A2 activity; protein binding

Biological Process: phospholipid metabolic process

NCBI Summary:Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UL19
NCBI GenInfo Identifier:20140910
NCBI Gene ID:5920
NCBI Accession:Q9UL19.1
UniProt Secondary Accession:Q9UL19,O95200, B2R599, B4DDW2, E7ENZ7,
UniProt Related Accession:Q9UL19
Molecular Weight:17,436 Da
NCBI Full Name:Retinoic acid receptor responder protein 3
NCBI Synonym Full Names:retinoic acid receptor responder 3
NCBI Official Symbol:RARRES3  
NCBI Official Synonym Symbols:RIG1; TIG3; HRSL4; HRASLS4; PLA1/2-3  
NCBI Protein Information:retinoic acid receptor responder protein 3
UniProt Protein Name:Retinoic acid receptor responder protein 3
UniProt Synonym Protein Names:HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein
Protein Family:Retinoic acid receptor responder protein
UniProt Gene Name:RARRES3  
UniProt Entry Name:HRSL4_HUMAN
Anti-RARRES3 Polyclonal Antibody (CAB8784)Western blot analysis of extracts of 293T cells, using RARRES3 antibody (CAB8784) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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