Cell Biology Antibodies 10
Anti-RARRES2 Antibody (CAB6963)
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- SKU:
- CAB6963
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RARRES2 Antibody |
| Antibody SKU: | CAB6963 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-163 of human RARRES2 (NP_002880.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, BT-474, HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-163 of human RARRES2 (NP_002880.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VGVA ELTE AQRR GLQV ALEE FHKH PPVQ WAFQ ETSV ESAV DTPF PAGI FVRL EFKL QQTS CRKR DWKK PECK VRPN GRKR KCLA CIKL GSED KVLG RLVH CPIE TQVL REAE EHQE TQCL RVQR AGED PHSF YFPG QFAF SKAL PRS |
| Gene ID: | 5919 |
| Uniprot: | Q99969 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | RARRES2, HP10433, TIG2 |
| Background: | This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. |
| UniProt Protein Function: | RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: extracellular matrix; extracellular region Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; chemotaxis; embryonic gut development; in utero embryonic development; inflammatory response; positive regulation of chemotaxis; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; regulation of lipid catabolic process; retinoid metabolic process |
| NCBI Summary: | This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q99969 |
| NCBI GenInfo Identifier: | 6226227 |
| NCBI Gene ID: | 5919 |
| NCBI Accession: | Q99969.1 |
| UniProt Secondary Accession: | Q99969,Q7LE02, |
| UniProt Related Accession: | Q99969 |
| Molecular Weight: | 18,618 Da |
| NCBI Full Name: | Retinoic acid receptor responder protein 2 |
| NCBI Synonym Full Names: | retinoic acid receptor responder 2 |
| NCBI Official Symbol: | RARRES2 |
| NCBI Official Synonym Symbols: | TIG2; HP10433 |
| NCBI Protein Information: | retinoic acid receptor responder protein 2 |
| UniProt Protein Name: | Retinoic acid receptor responder protein 2 |
| UniProt Synonym Protein Names: | Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein |
| Protein Family: | Retinoic acid receptor responder protein |
| UniProt Gene Name: | RARRES2 |
| UniProt Entry Name: | RARR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RARRES2 antibody (CAB6963) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15min. |
 | Immunohistochemistry of paraffin-embedded Mouse kidney using RARRES2 Rabbit pAb (CAB6963) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat kidney using RARRES2 Rabbit pAb (CAB6963) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human liver using RARRES2 Rabbit pAb (CAB6963) at dilution of 1:50 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using RARRES2 antibody (CAB6963). Blue: DAPI for nuclear staining. |
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