Epigenetics & Nuclear Signaling Antibodies 1

Anti-RARB Antibody (CAB13173)

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SKU:
CAB13173
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-RARB Antibody
Antibody SKU:CAB13173
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 146-370 of human RARB (NP_000956.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 146-370 of human RARB (NP_000956.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSKE SVRN DRNK KKKE TSKQ ECTE SYEM TAEL DDLT EKIR KAHQ ETFP SLCQ LGKY TTNS SADH RVRL DLGL WDKF SELA TKCI IKIV EFAK RLPG FTGL TIAD QITL LKAA CLDI LILR ICTR YTPE QDTM TFSD GLTL NRTQ MHNA GFGP LTDL VFTF ANQL LPLE MDDT ETGL LSAI CLIC GDRQ DLEE PTKV DKLQ EPLL EALK IYIR KRRP SKPH MFPK I
Gene ID:5915
Uniprot:P10826
Cellular Location:Cytoplasm, Nucleus, Nucleus
Calculated MW:37kDa/50kDa
Observed MW:50kDa
Synonyms:RARB, HAP, MCOPS12, NR1B2, RARbeta1, RRB2
Background:This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants.
UniProt Protein Function:RARB: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Oncoprotein; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; protein complex binding; steroid hormone receptor activity; drug binding; retinoic acid receptor activity

Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of myelination; glandular epithelial cell development; striatum development; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; positive regulation of neuron differentiation; embryonic gut development; transmembrane transport; negative regulation of apoptosis

Disease: Microphthalmia, Syndromic 12

NCBI Summary:This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:P10826
NCBI GenInfo Identifier:17380507
NCBI Gene ID:5915
NCBI Accession:P10826.2
UniProt Secondary Accession:P10826,P12891, Q00989, Q15298, Q9UN48,
UniProt Related Accession:P10826
Molecular Weight:– Da
NCBI Full Name:Retinoic acid receptor beta
NCBI Synonym Full Names:retinoic acid receptor, beta
NCBI Official Symbol:RARB  
NCBI Official Synonym Symbols:HAP; RRB2; NR1B2; MCOPS12  
NCBI Protein Information:retinoic acid receptor beta; RAR-beta; RAR-epsilon; HBV-activated protein; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2
UniProt Protein Name:Retinoic acid receptor beta
UniProt Synonym Protein Names:HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon
Protein Family:Retinoic acid receptor
UniProt Gene Name:RARB  
UniProt Entry Name:RARB_HUMAN
Anti-RARB Antibody (CAB13173)Western blot analysis of extracts of Raji cells, using RARB antibody (CAB13173) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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