Cell Biology Antibodies 9

Anti-RAPGEF4 Antibody (CAB4484)

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SKU:
CAB4484
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RAPGEF4
Synonyms:
CAMP-GEFII
Synonyms:
CGEF2
Synonyms:
EPAC
Synonyms:
EPAC 2
Synonyms:
EPAC2
Synonyms:
Nbla00496
Research Area:
Cell Biology

Description

Product Name:RAPGEF4 Rabbit pAb
Product Code:CAB4484
Size:20uL, 50uL, 100uL
Synonyms:RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, SW620, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLYK KYRQ YMAG LLAP PYGV METG SNND RIPD KENT PLIE PHVP LRPA NTIT KVPS EKIL RAGK ILRN AILS RAPH MIRD RKYH LKTY RQCC VGTE LVDW MMQQ TPCV HSRT QAVG MWQV LLED GVLN HVDQ EHHF QDKY LFYR FLDD EHED APLP TEEE KKEC DEEL QDTM LLLS QMGP DAHM RMIL RKPP GQRT VDDL EIIY EELL HI
Gene ID:11069
Uniprot:Q8WZA2
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:79kDa/96kDa/98kDa/99kDa/115kDa
Observed MW:115kDa
UniProt Protein Function:RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:

Protein type:GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 2q31-q32

Cellular Component: membrane; plasma membrane; cytosol; cAMP-dependent protein kinase complex

Molecular Function:protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: regulation of exocytosis; G-protein coupled receptor protein signaling pathway; platelet activation; cAMP-mediated signaling; insulin secretion; small GTPase mediated signal transduction; energy reserve metabolic process; blood coagulation; regulation of protein kinase activity; regulation of insulin secretion; calcium ion-dependent exocytosis

UniProt Code:Q8WZA2
NCBI GenInfo Identifier:32171491
NCBI Gene ID:11069
NCBI Accession:Q8WZA2.1
UniProt Secondary Accession:Q8WZA2,Q9EQZ6, Q9Z1C7,
UniProt Related Accession:Q8WZA2
Molecular Weight:1011
NCBI Full Name:Rap guanine nucleotide exchange factor 4
NCBI Synonym Full Names:Rap guanine nucleotide exchange factor (GEF) 4
NCBI Official Symbol:RAPGEF4  
NCBI Official Synonym Symbols:2; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII  
NCBI Protein Information:rap guanine nucleotide exchange factor 4; putative protein product of Nbla00496; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; RAP guanine-nucleotide-exchange factor (GEF) 4; cAMP-regulated guanine nucleotide
UniProt Protein Name:Rap guanine nucleotide exchange factor 4
UniProt Synonym Protein Names:Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; EPAC 2; cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII
UniProt Gene Name:RAPGEF4  
UniProt Entry Name:RPGF4_HUMAN
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