Cell Biology Antibodies 9
Anti-RAPGEF4 Antibody (CAB4484)
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- SKU:
- CAB4484
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RAPGEF4
- Synonyms:
- CAMP-GEFII
- Synonyms:
- CGEF2
- Synonyms:
- EPAC
- Synonyms:
- EPAC 2
- Synonyms:
- EPAC2
- Synonyms:
- Nbla00496
- Research Area:
- Cell Biology
Description
| Product Name: | RAPGEF4 Rabbit pAb |
| Product Code: | CAB4484 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, SW620, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human RAPGEF4 (NP_001093867.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLYK KYRQ YMAG LLAP PYGV METG SNND RIPD KENT PLIE PHVP LRPA NTIT KVPS EKIL RAGK ILRN AILS RAPH MIRD RKYH LKTY RQCC VGTE LVDW MMQQ TPCV HSRT QAVG MWQV LLED GVLN HVDQ EHHF QDKY LFYR FLDD EHED APLP TEEE KKEC DEEL QDTM LLLS QMGP DAHM RMIL RKPP GQRT VDDL EIIY EELL HI |
| Gene ID: | 11069 |
| Uniprot: | Q8WZA2 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein |
| Calculated MW: | 79kDa/96kDa/98kDa/99kDa/115kDa |
| Observed MW: | 115kDa |
| UniProt Protein Function: | RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Ras Chromosomal Location of Human Ortholog: 2q31-q32 Cellular Component: membrane; plasma membrane; cytosol; cAMP-dependent protein kinase complex Molecular Function:protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding; Ras guanyl-nucleotide exchange factor activity Biological Process: regulation of exocytosis; G-protein coupled receptor protein signaling pathway; platelet activation; cAMP-mediated signaling; insulin secretion; small GTPase mediated signal transduction; energy reserve metabolic process; blood coagulation; regulation of protein kinase activity; regulation of insulin secretion; calcium ion-dependent exocytosis |
| UniProt Code: | Q8WZA2 |
| NCBI GenInfo Identifier: | 32171491 |
| NCBI Gene ID: | 11069 |
| NCBI Accession: | Q8WZA2.1 |
| UniProt Secondary Accession: | Q8WZA2,Q9EQZ6, Q9Z1C7, |
| UniProt Related Accession: | Q8WZA2 |
| Molecular Weight: | 1011 |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 4 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor (GEF) 4 |
| NCBI Official Symbol: | RAPGEF4 |
| NCBI Official Synonym Symbols: | 2; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 4; putative protein product of Nbla00496; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; RAP guanine-nucleotide-exchange factor (GEF) 4; cAMP-regulated guanine nucleotide |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 4 |
| UniProt Synonym Protein Names: | Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; EPAC 2; cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII |
| UniProt Gene Name: | RAPGEF4 |
| UniProt Entry Name: | RPGF4_HUMAN |
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