Cardiovascular Antibodies

Anti-RAPGEF3 Antibody (CAB2199)

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SKU:
CAB2199
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-RAPGEF3 Antibody
Antibody SKU:CAB2199
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAPGEF3 (NP_001092002.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples: Mouse heart, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAPGEF3 (NP_001092002.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVLR RMHR PRSC SYQL LLEH QRPS CIQG LRWT PLTN SEES LDFS ESLE QAST ERVL RAGR QLHR HLLA TCPN LIRD RKYH LRLY RQCC SGRE LVDG ILAL GLGV HSRS QVVG ICQV LLDE GALC HVKH DWAF QDRD AQFY RFPG PEPE PVGT HEME EELA EAVA LLSQ RGPD ALLT VALR KPPG QRTD EELD LIFE ELLH
Gene ID:10411
Uniprot:O95398
Cellular Location:Endomembrane system
Calculated MW:66kDa/99kDa/103kDa
Observed MW:104kDa
Synonyms:RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910
Background:
UniProt Protein Function:Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GEFs, misc.; GEFs

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex

Molecular Function:Rap guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding

Biological Process: positive regulation of syncytium formation by plasma membrane fusion; platelet activation; signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; cell proliferation; positive regulation of angiogenesis; cAMP-mediated signaling; positive regulation of stress fiber formation; energy reserve metabolic process; positive regulation of cAMP catabolic process; angiogenesis; blood coagulation; regulation of protein kinase activity; regulation of insulin secretion; Rap protein signal transduction

UniProt Code:O95398
NCBI GenInfo Identifier:317373593
NCBI Gene ID:10411
NCBI Accession:O95398.6
UniProt Related Accession:O95398
Molecular Weight:
NCBI Full Name:Rap guanine nucleotide exchange factor 3
NCBI Synonym Full Names:Rap guanine nucleotide exchange factor 3
NCBI Official Symbol:RAPGEF3  
NCBI Official Synonym Symbols:EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI  
NCBI Protein Information:rap guanine nucleotide exchange factor 3
UniProt Protein Name:Rap guanine nucleotide exchange factor 3
UniProt Synonym Protein Names:Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I
UniProt Gene Name:RAPGEF3  
UniProt Entry Name:RPGF3_HUMAN
Anti-RAPGEF3 Antibody (CAB2199)Western blot analysis of extracts of various cell lines, using RAPGEF3 antibody (CAB2199) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-RAPGEF3 Antibody (CAB2199)Immunofluorescence analysis of U2OS cells using RAPGEF3 antibody (CAB2199). Blue: DAPI for nuclear staining.
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