Cell Biology Antibodies 8
Anti-RAP2A Antibody (CAB2616)
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- SKU:
- CAB2616
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RAP2A Antibody |
| Antibody SKU: | CAB2616 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human RAP2A (NP_066361.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, Raji, SW620, Mouse brain, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human RAP2A (NP_066361.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MREY KVVV LGSG GVGK SALT VQFV TGTF IEKY DPTI EDFY RKEI EVDS SPSV LEIL DTAG TEQF ASMR DLYI KNGQ GFIL VYSL VNQQ SFQD IKPM RDQI IRVK RYEK VPVI LVGN KVDL ESER EVSS SEGR ALAE EWGC PFME TSAK SKTM VDEL FAEI VRQM NYAA QPDK DDPC CSAC NIQ |
| Gene ID: | 5911 |
| Uniprot: | P10114 |
| Cellular Location: | Cytoplasmic side, Lipid-anchor, Midbody, Recycling endosome membrane |
| Calculated MW: | 20kDa |
| Observed MW: | 21kDa |
| Synonyms: | RAP2A, K-REV, KREV, RAP2, RbBP-30 |
| Background: |
| UniProt Protein Function: | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. |
| UniProt Code: | P10114 |
| NCBI GenInfo Identifier: | 131852 |
| NCBI Gene ID: | 5911 |
| NCBI Accession: | P10114.1 |
| UniProt Secondary Accession: | P10114,Q5JSC1, Q5JSC2, B2RCJ1, |
| UniProt Related Accession: | P10114 |
| Molecular Weight: | 20,615 Da |
| NCBI Full Name: | Ras-related protein Rap-2a |
| NCBI Synonym Full Names: | RAP2A, member of RAS oncogene family |
| NCBI Official Symbol: | RAP2A |
| NCBI Official Synonym Symbols: | KREV; RAP2; K-REV; RbBP-30 |
| NCBI Protein Information: | ras-related protein Rap-2a |
| UniProt Protein Name: | Ras-related protein Rap-2a |
| UniProt Synonym Protein Names: | RbBP-30 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAP2A |
| UniProt Entry Name: | RAP2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RAP2A antibody (CAB2616) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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