Anti-Rap1GAP Antibody (CAB3621)
- SKU:
- CAB3621
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RAP1GA1
- Synonyms:
- RAP1GAP1
- Synonyms:
- RAP1GAPII
- Synonyms:
- RAPGAP
- Research Area:
- Cell Biology
Description
| Product Name: | Rap1GAP Rabbit mAb |
| Product Code: | CAB3621 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Rap1GAP |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, U-87MG, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human Rap1GAP |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5909 |
| Uniprot: | P47736 |
| Cellular Location: | Golgi apparatus membrane, Peripheral membrane protein |
| Calculated MW: | 95kDa |
| Observed MW: | 95kDa |
| UniProt Protein Function: | RAP1GAP: a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
| UniProt Protein Details: | Protein type:GAP; GAP, Ras; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p36.12 Cellular Component: cytosol; membrane Molecular Function:GTPase activator activity; protein binding; protein homodimerization activity; Ras GTPase binding Biological Process: axon guidance; positive regulation of GTPase activity; regulation of GTPase activity |
| NCBI Summary: | This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P47736 |
| NCBI GenInfo Identifier: | 215273877 |
| NCBI Gene ID: | 5909 |
| NCBI Accession: | P47736.2 |
| UniProt Secondary Accession: | P47736,O75062, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51, J3QSS6 |
| UniProt Related Accession: | P47736 |
| Molecular Weight: | 73kDa |
| NCBI Full Name: | Rap1 GTPase-activating protein 1 |
| NCBI Synonym Full Names: | RAP1 GTPase activating protein |
| NCBI Official Symbol: | RAP1GAP |
| NCBI Official Synonym Symbols: | RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII |
| NCBI Protein Information: | rap1 GTPase-activating protein 1 |
| UniProt Protein Name: | Rap1 GTPase-activating protein 1 |
| Protein Family: | Rap1 GTPase-activating protein |
| UniProt Gene Name: | RAP1GAP |
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