Name: Anti-RANBP9 Antibody (CAB12097)
Brand: Cell Biology Antibodies 2
SKU: CAB12097
Availability: OutOfStock

Antibody Name:	Anti-RANBP9 Antibody
Antibody SKU:	CAB12097
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 480-605 of human RANBP9 (NP_005484.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:1000
Reactivity:	Human
Positive Samples:	Raji, A-549, B cells

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 480-605 of human RANBP9 (NP_005484.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	PFSS PSMS PSHG MNIH NLAS GKGS TAHF SGFE SCSN GVIS NKAH QSYC HSNK HQSS NLNV PELN SINM SRSQ QVNN FTSN DVDM ETDH YSNG VGET SSNG FLNG SSKH DHEM EDCD TEME VDSS QL
Gene ID:	10048
Uniprot:	Q96S59
Cellular Location:	Cytoplasm, Nucleus, cytosol
Calculated MW:	43kDa/55kDa/77kDa
Observed MW:	100kDa

Synonyms:

RANBP9, BPM-L, BPM90, RANBPM, RanBP7

Background:

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.

UniProt Protein Function:	RANBP9: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Belongs to the RANBP9/10 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Nuclear receptor co-regulator; Adaptor/scaffold; GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 6p23 Cellular Component: microtubule associated complex; nucleus; cytosol Molecular Function:protein binding; enzyme binding; Ran GTPase binding Biological Process: axon guidance; protein complex assembly; microtubule nucleation
NCBI Summary:	This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
UniProt Code:	Q96S59
NCBI GenInfo Identifier:	61215334
NCBI Gene ID:	10048
NCBI Accession:	Q96S59.1
UniProt Related Accession:	Q96S59
Molecular Weight:	42kDa
NCBI Full Name:	Ran-binding protein 9
NCBI Synonym Full Names:	RAN binding protein 9
NCBI Official Symbol:	RANBP9
NCBI Official Synonym Symbols:	BPM-L; BPM90; RANBPM; RanBP7
NCBI Protein Information:	ran-binding protein 9
UniProt Protein Name:	Ran-binding protein 9
UniProt Synonym Protein Names:	BPM-L; BPM90; Ran-binding protein M; RanBPM; RanBP7
Protein Family:	Ran-binding protein
UniProt Gene Name:	RANBP9
UniProt Entry Name:	RANB9_HUMAN

Western blot analysis of extracts of various cell lines, using RANBP9 antibody (CAB12097) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

RANBP9 Antibody (PACO11712)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)