Anti-RANBP3 Antibody (CAB0092)
- SKU:
- CAB0092
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RANBP3
- Synonyms:
- ran-binding protein 3
- Research Area:
- Cell Biology
Description
| Product Name: | RANBP3 Rabbit mAb |
| Product Code: | CAB0092 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RANBP3, ran-binding protein 3 |
| Applications: | IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RANBP3. |
| Applications: | IHC |
| Recommended Dilutions: | IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human RANBP3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8498 |
| Uniprot: | Q9H6Z4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 70, 90kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | RANBP3: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling. Widely expressed with high levels in testis and heart. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: positive regulation of protein export from nucleus |
| NCBI Summary: | This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H6Z4 |
| NCBI GenInfo Identifier: | 51316528 |
| NCBI Gene ID: | 8498 |
| NCBI Accession: | Q9H6Z4.1 |
| UniProt Secondary Accession: | Q9H6Z4,O60405, O75759, O75760, Q9BT47, Q9UG74, B2RAT8 |
| UniProt Related Accession: | Q9H6Z4 |
| Molecular Weight: | 53,411 Da |
| NCBI Full Name: | Ran-binding protein 3 |
| NCBI Synonym Full Names: | RAN binding protein 3 |
| NCBI Official Symbol: | RANBP3 |
| NCBI Protein Information: | ran-binding protein 3 |
| UniProt Protein Name: | Ran-binding protein 3 |
| Protein Family: | Ran-binding protein |
| UniProt Gene Name: | RANBP3 |
| UniProt Entry Name: | RANB3_HUMAN |
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