Anti-RANBP3 Antibody (CAB0092)

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SKU:
CAB0092
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RANBP3
Synonyms:
ran-binding protein 3
Research Area:
Cell Biology

Description

Product Name:RANBP3 Rabbit mAb
Product Code:CAB0092
Size:20uL, 50uL, 100uL
Synonyms:RANBP3, ran-binding protein 3
Applications:IHC
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RANBP3.
Applications:IHC
Recommended Dilutions:IHC 1:50 - 1:200
Reactivity:Mouse, Rat
Immunogen:A synthesized peptide derived from human RANBP3.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8498
Uniprot:Q9H6Z4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:70, 90kDa
Observed MW:Refer to figures
UniProt Protein Function:RANBP3: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling. Widely expressed with high levels in testis and heart. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: positive regulation of protein export from nucleus

NCBI Summary:This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H6Z4
NCBI GenInfo Identifier:51316528
NCBI Gene ID:8498
NCBI Accession:Q9H6Z4.1
UniProt Secondary Accession:Q9H6Z4,O60405, O75759, O75760, Q9BT47, Q9UG74, B2RAT8
UniProt Related Accession:Q9H6Z4
Molecular Weight:53,411 Da
NCBI Full Name:Ran-binding protein 3
NCBI Synonym Full Names:RAN binding protein 3
NCBI Official Symbol:RANBP3  
NCBI Protein Information:ran-binding protein 3
UniProt Protein Name:Ran-binding protein 3
Protein Family:Ran-binding protein
UniProt Gene Name:RANBP3  
UniProt Entry Name:RANB3_HUMAN
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