Cell Biology Antibodies 13

Anti-RANBP10 Antibody (CAB17742)

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SKU:
CAB17742
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RANBP10 Antibody
Antibody SKU:CAB17742
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HeLa, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YPGS PSLS PRHG PSSS HMHN TGAD SPSC SNGV ASTK SKQN HSKY PAPS SSSS SSSS SSSS SPSS VNYS ESNS TDST KSQH HSST SNQE TSDS EMEM EAEH YPNG VLGS MSTR IVNG AYKH EDLQ TDES SMDD RHPR
Gene ID:57610
Uniprot:Q6VN20
Cellular Location:
Calculated MW:58kDa/64kDa/67kDa
Observed MW:73kDa
Anti-RANBP10 Antibody (CAB17742)Western blot - RANBP10 Polyclonal Antibody (CAB17742)
Synonyms:RANBP10
Background:RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
UniProt Protein Function:RANBP10: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function. May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway. Belongs to the RANBP9/10 family.
UniProt Protein Details:

Protein type:GEFs; GEFs, Ras; GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasmic microtubule; cytosol; nucleus

Molecular Function:Ran guanyl-nucleotide exchange factor activity; beta-tubulin binding; Ran GTPase binding

Biological Process: microtubule cytoskeleton organization and biogenesis

NCBI Summary:RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
UniProt Code:Q6VN20
NCBI GenInfo Identifier:119603573
NCBI Gene ID:57610
NCBI Accession:EAW83167
UniProt Related Accession:Q6VN20
Molecular Weight:
NCBI Full Name:RAN binding protein 10, isoform CRA_a
NCBI Synonym Full Names:RAN binding protein 10
NCBI Official Symbol:RANBP10  
NCBI Protein Information:ran-binding protein 10
UniProt Protein Name:Ran-binding protein 10
UniProt Gene Name:RANBP10  
UniProt Entry Name:RBP10_HUMAN
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