Signal Transduction Antibodies 3
Anti-RAMP2 Antibody (CAB17072)
- SKU:
- CAB17072
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-RAMP2 Antibody |
| Antibody SKU: | CAB17072 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human RAMP2. |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human RAMP2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10266 |
| Uniprot: | O60895 |
| Cellular Location: | |
| Calculated MW: | 19kDa/20kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RAMP2 |
| Background: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. |
| UniProt Protein Function: | RAMP2: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17q12-q21.1 Cellular Component: cell surface; integral to plasma membrane; lysosome; cytoplasm; plasma membrane; coated pit; receptor complex Molecular Function:protein binding; coreceptor activity; protein transporter activity Biological Process: heart development; female pregnancy; response to estradiol stimulus; cellular response to hormone stimulus; intracellular protein transport; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; protein transport; receptor internalization; calcium ion transport; regulation of blood pressure; positive regulation of cAMP biosynthetic process; response to hypoxia; negative regulation of vascular permeability; cAMP biosynthetic process; angiogenesis; sprouting angiogenesis; vasculogenesis; response to progesterone stimulus; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60895 |
| NCBI GenInfo Identifier: | 27735250 |
| NCBI Gene ID: | 10266 |
| NCBI Accession: | O60895.2 |
| UniProt Related Accession: | O60895 |
| Molecular Weight: | ~20kDa |
| NCBI Full Name: | Receptor activity-modifying protein 2 |
| NCBI Synonym Full Names: | receptor activity modifying protein 2 |
| NCBI Official Symbol: | RAMP2 |
| NCBI Protein Information: | receptor activity-modifying protein 2 |
| UniProt Protein Name: | Receptor activity-modifying protein 2 |
| UniProt Synonym Protein Names: | Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2 |
| Protein Family: | Receptor activity-modifying protein |
| UniProt Gene Name: | RAMP2 |
| UniProt Entry Name: | RAMP2_HUMAN |
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