Anti-RAIDD/CRADD Antibody (CAB8663)
- SKU:
- CAB8663
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MRT34
- Synonyms:
- RAIDD
- Research Area:
- Cell Death
Description
| Product Name: | RAIDD/CRADD Rabbit mAb |
| Product Code: | CAB8663 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MRT34, RAIDD |
| Applications: | WB, IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RAIDD/CRADD |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HT-29, 293T, K-562 |
| Immunogen: | A synthesized peptide derived from human RAIDD/CRADD |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8738 |
| Uniprot: | P78560 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
| UniProt Protein Function: | CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Chromosomal Location of Human Ortholog: 12q21.33-q23.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding, bridging; protein binding; protease binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Disease: Mental Retardation, Autosomal Recessive 34 |
| NCBI Summary: | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P78560 |
| NCBI GenInfo Identifier: | 2498833 |
| NCBI Gene ID: | 8738 |
| NCBI Accession: | P78560.1 |
| UniProt Related Accession: | P78560 |
| Molecular Weight: | ~ 23kDa |
| NCBI Full Name: | Death domain-containing protein CRADD |
| NCBI Synonym Full Names: | CASP2 and RIPK1 domain containing adaptor with death domain |
| NCBI Official Symbol: | CRADD |
| NCBI Official Synonym Symbols: | MRT34; RAIDD |
| NCBI Protein Information: | death domain-containing protein CRADD |
| UniProt Protein Name: | Death domain-containing protein CRADD |
| UniProt Synonym Protein Names: | Caspase and RIP adapter with death domain; RIP-associated protein with a death domain |
| UniProt Gene Name: | CRADD |
| UniProt Entry Name: | CRADD_HUMAN |
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