Anti-RAIDD/CRADD Antibody (CAB8663)

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SKU:
CAB8663
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MRT34
Synonyms:
RAIDD
Research Area:
Cell Death

Description

Product Name:RAIDD/CRADD Rabbit mAb
Product Code:CAB8663
Size:20uL, 50uL, 100uL
Synonyms:MRT34, RAIDD
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RAIDD/CRADD
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HT-29, 293T, K-562
Immunogen:A synthesized peptide derived from human RAIDD/CRADD
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8738
Uniprot:P78560
Cellular Location:Cytoplasm, Nucleus
Calculated MW:23kDa
Observed MW:23kDa
UniProt Protein Function:CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 12q21.33-q23.1

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding, bridging; protein binding; protease binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Disease: Mental Retardation, Autosomal Recessive 34

NCBI Summary:This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Code:P78560
NCBI GenInfo Identifier:2498833
NCBI Gene ID:8738
NCBI Accession:P78560.1
UniProt Related Accession:P78560
Molecular Weight:~ 23kDa
NCBI Full Name:Death domain-containing protein CRADD
NCBI Synonym Full Names:CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Official Symbol:CRADD  
NCBI Official Synonym Symbols:MRT34; RAIDD  
NCBI Protein Information:death domain-containing protein CRADD
UniProt Protein Name:Death domain-containing protein CRADD
UniProt Synonym Protein Names:Caspase and RIP adapter with death domain; RIP-associated protein with a death domain
UniProt Gene Name:CRADD  
UniProt Entry Name:CRADD_HUMAN
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