| UniProt Protein Function: | RAD54L: Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. Belongs to the SNF2/RAD54 helicase family.Protein type: EC 3.6.4.-; DNA repair, damage; Cell cycle regulation; Helicase; EC 3.6.1.-Chromosomal Location of Human Ortholog: 1p32Cellular Component: nucleoplasm; nucleusMolecular Function: ATP binding; DNA binding; helicase activity; protein bindingBiological Process: chromosome organization and biogenesis; determination of adult life span; DNA recombination; DNA repair; DNA strand renaturation; double-strand break repair via homologous recombination; meiosis; response to drug; response to ionizing radiationDisease: Breast Cancer; Lymphoma, Non-hodgkin, Familial |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008] |
| UniProt Code: | Q92698 |
| NCBI GenInfo Identifier: | 51316508 |
| NCBI Gene ID: | 8438 |
| NCBI Accession: | Q92698.2 |
| UniProt Secondary Accession: | Q92698,Q5TE31, Q6IUY3 |
| UniProt Related Accession: | Q92698 |
| Molecular Weight: | 84,352 Da |
| NCBI Full Name: | DNA repair and recombination protein RAD54-like |
| NCBI Synonym Full Names: | RAD54-like (S. cerevisiae) |
| NCBI Official Symbol: | RAD54L |
| NCBI Official Synonym Symbols: | HR54; hHR54; RAD54A; hRAD54 |
| NCBI Protein Information: | DNA repair and recombination protein RAD54-like |
| UniProt Protein Name: | DNA repair and recombination protein RAD54-like |
| UniProt Synonym Protein Names: | RAD54 homolog; hHR54; hRAD54 |
| Protein Family: | |
| UniProt Gene Name: | RAD54L |
| UniProt Entry Name: | RAD54_HUMAN |
