Epigenetics & Nuclear Signaling Antibodies 5

Anti-Rad52 Antibody (CAB5186)

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SKU:
CAB5186
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-Rad52 Antibody
Antibody SKU:CAB5186
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Rad52
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, 293T, PC-3
Immunogen:A synthesized peptide derived from human Rad52
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5893
Uniprot:P43351
Cellular Location:Nucleus
Calculated MW:48kDa
Observed MW:50KDa
Synonyms:RAD52, DNA repair protein RAD52 homolog
Background:The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
UniProt Protein Function:RAD52: a protein involved in DNA double strand breaks and recombination. Associates with and is phosphorylated by c-Abl. Belongs to the RAD52/RAD22 family.
UniProt Protein Details:

Protein type:DNA repair, damage

Chromosomal Location of Human Ortholog: 12p13-p12.2

Cellular Component: nucleoplasm; nucleus; protein complex

Molecular Function:DNA binding; identical protein binding; protein binding

Biological Process: DNA recombination; double-strand break repair; protein sumoylation; response to DNA damage stimulus

NCBI Summary:The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
UniProt Code:P43351
NCBI GenInfo Identifier:1172823
NCBI Gene ID:5893
NCBI Accession:P43351.1
UniProt Secondary Accession:P43351,Q13205, Q9Y5T7, Q9Y5T8, Q9Y5T9,
UniProt Related Accession:P43351
Molecular Weight:12,943 Da
NCBI Full Name:DNA repair protein RAD52 homolog
NCBI Synonym Full Names:RAD52 homolog, DNA repair protein
NCBI Official Symbol:RAD52  
NCBI Protein Information:DNA repair protein RAD52 homolog
UniProt Protein Name:DNA repair protein RAD52 homolog
Protein Family:RAD52 motif-containing protein
UniProt Gene Name:RAD52  
UniProt Entry Name:RAD52_HUMAN
Anti-Rad52 Antibody (CAB5186)Western blot - Rad52 Rabbit mAb (CAB5186)
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