Antibody Name:	Anti-RAD51B Antibody
Antibody SKU:	CAB14169
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human RAD51B (NP_598193.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human RAD51B (NP_598193.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGSK KLKR VGLS QELC DRLS RHQI LTCQ DFLC LSPL ELMK VTGL SYRG VHEL LCMV SRAC APKM QTAY GIKA QRSA DFSP AFLS TTLS ALDE ALHG GVAC GSLT EITG PPGC GKTQ FCIM MSIL ATLP TNMG GLEG AVVY IDTE SAFS AERL VEIA ESRF PRYF NTEE KLLL TSSK VHLY RELT CDEV LQRI ESLE EEII SKGI KLVI LDSV ASVV RKEF DAQL QGNL KERN KFLA REAS SLKY LAEE FSIP VILT NQIT THLS GALA SQAD LVSP ADDL SLSE GTSG SSCV IAAL GNTW SHSV NTRL ILQY LDSE RRQI LIAK SPLA PFTS FVYT IKEE GLVL QETT FCSV TQAE LNWA PEIL PPQP PEQL GLQM CHHT QLIF
Gene ID:	5890
Uniprot:	O15315
Cellular Location:	Nucleus
Calculated MW:	25kDa/38kDa/40kDa/42kDa
Observed MW:	Refer to figures

Synonyms:

RAD51B, R51H2, RAD51L1, REC2

Background:

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.

UniProt Protein Function:	RAD51L1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B- RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single- stranded gaps in duplex DNA and specifically to nicks in duplex DNA. A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23- 24) with HMGA1. A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2. Belongs to the RecA family. RAD51 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 14q23-q24.2 Cellular Component: nucleoplasm; replication fork; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; DNA binding; double-stranded DNA binding; single-stranded DNA binding; ATP binding Biological Process: meiotic recombination; blood coagulation; DNA repair; double-strand break repair via homologous recombination; DNA recombination Disease: Leiomyoma, Uterine
NCBI Summary:	The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]
UniProt Code:	O15315
NCBI GenInfo Identifier:	38258892
NCBI Gene ID:	5890
NCBI Accession:	O15315.2
UniProt Secondary Accession:	O15315,O60914, O75210, Q3Y4F8, Q6FHX8, Q86SY3, Q86SY4 Q86TR0, Q86U92, Q86U93, Q86U94, Q8N6H4,
UniProt Related Accession:	O15315
Molecular Weight:	384
NCBI Full Name:	DNA repair protein RAD51 homolog 2
NCBI Synonym Full Names:	RAD51 paralog B
NCBI Official Symbol:	RAD51B
NCBI Official Synonym Symbols:	REC2; R51H2; RAD51L1
NCBI Protein Information:	DNA repair protein RAD51 homolog 2; RAD51 homolog B; RecA-like protein; recombination repair protein
UniProt Protein Name:	DNA repair protein RAD51 homolog 2
UniProt Synonym Protein Names:	RAD51 homolog B; Rad51B; RAD51-like protein 1
UniProt Gene Name:	RAD51B
UniProt Entry Name:	RA51B_HUMAN