Cell Biology Antibodies 8

Anti-RAB8B Antibody (CAB3678)

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SKU:
CAB3678
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RAB8B Antibody
Antibody SKU:CAB3678
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human RAB8B (NP_057614.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human RAB8B (NP_057614.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKT YDYL FKLL LIGD SGVG KTCL LFRF SEDA FNTT FIST IGID FKIR TIEL DGKK IKLQ IWDT AGQE RFRT ITTA YYRG AMGI MLVY DITN EKSF DNIK NWIR NIEE HASS DVER MILG NKCD MNDK RQVS KERG EKLA IDYG IKFL ETSA KSSA NVEE AFFT LARD IMTK LNRK MNDS NSAG AGGP VKIT ENRS KKTS FFRC SLL
Gene ID:51762
Uniprot:Q92930
Cellular Location:Cell membrane, Cytoplasmic side, Cytoplasmic vesicle, Lipid-anchor, phagosome, phagosome membrane
Calculated MW:23kDa
Observed MW:23KDa
Synonyms:RAB8B
Background:RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
UniProt Protein Function:RAB8B: May be involved in vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:

Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: peroxisomal membrane; phagocytic vesicle

Molecular Function:GDP binding; protein binding; receptor binding

Biological Process: antigen processing and presentation; cilium biogenesis; protein import into peroxisome membrane; protein secretion; vesicle docking during exocytosis

NCBI Summary:RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
UniProt Code:Q92930
NCBI GenInfo Identifier:13638434
NCBI Gene ID:51762
NCBI Accession:Q92930.2
UniProt Secondary Accession:Q92930,Q5JPC4, Q9P293,
UniProt Related Accession:Q92930
Molecular Weight:23,584 Da
NCBI Full Name:Ras-related protein Rab-8B
NCBI Synonym Full Names:RAB8B, member RAS oncogene family
NCBI Official Symbol:RAB8B  
NCBI Protein Information:ras-related protein Rab-8B
UniProt Protein Name:Ras-related protein Rab-8B
Protein Family:Ras-related protein
UniProt Gene Name:RAB8B  
UniProt Entry Name:RAB8B_HUMAN
Anti-RAB8B Antibody (CAB3678)Western blot analysis of extracts of U-87MG cells, using RAB8B Rabbit pAb (CAB3678) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
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