Cell Biology Antibodies 15
Anti-RAB7B Antibody (CAB17855)
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- SKU:
- CAB17855
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RAB7B Antibody |
| Antibody SKU: | CAB17855 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse testis, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNPR KKVD LKLI IVGA IGVG KTSL LHQY VHKT FYEE YQTT LGAS ILSK IIIL GDTT LKLQ IWDT GGQE RFRS MVST FYKG SDGC ILAF DVTD LESF EALD IWRG DVLA KIVP MEQS YPMV LLGN KIDL ADRK VPQE VAQG WCRE KDIP YFEV SAKN DINV VQAF EMLA SRAL SRYQ SILE NHLT ESIK LSPD QSRS RCC |
| Gene ID: | 338382 |
| Uniprot: | Q96AH8 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 23kDa |
 | Western blot - RAB7B Rabbit pAb (CAB17855) |
| Synonyms: | RAB7, RAB7B |
| Background: |
| UniProt Protein Function: | RAB7B: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 1q32 Cellular Component: Golgi apparatus; phagocytic vesicle membrane; lysosome; late endosome; trans-Golgi network; phagocytic vesicle Molecular Function:GTP binding Biological Process: negative regulation of toll-like receptor 9 signaling pathway; protein transport; small GTPase mediated signal transduction; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation; activation of NF-kappaB transcription factor |
| UniProt Code: | Q96AH8 |
| NCBI GenInfo Identifier: | 256985158 |
| NCBI Gene ID: | 338382 |
| NCBI Accession: | NP_796377 |
| UniProt Related Accession: | Q96AH8 |
| Molecular Weight: | |
| NCBI Full Name: | ras-related protein Rab-7b isoform a |
| NCBI Synonym Full Names: | RAB7B, member RAS oncogene family |
| NCBI Official Symbol: | RAB7B |
| NCBI Official Synonym Symbols: | RAB7 |
| NCBI Protein Information: | ras-related protein Rab-7b |
| UniProt Protein Name: | Ras-related protein Rab-7b |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB7B |
| UniProt Entry Name: | RAB7B_HUMAN |
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