Cell Biology Antibodies 17

Anti-RAB4A Antibody (CAB3979)

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SKU:
CAB3979
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RAB4A Antibody
Antibody SKU:CAB3979
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RAB4A
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse brain
Immunogen:A synthesized peptide derived from human RAB4A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5867
Uniprot:P20338
Cellular Location:
Calculated MW:24kDa
Observed MW:25KDa
Synonyms:HRES-1, HRES-1/RAB4, HRES1, RAB4
Background:This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
UniProt Protein Function:Rab4: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 1q42-q43

Cellular Component: membrane; perinuclear region of cytoplasm; vesicle; endosome

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; protein transporter activity

Biological Process: antigen processing and presentation; intracellular protein transport; metabolic process; regulation of endocytosis; Rab protein signal transduction

NCBI Summary:This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:P20338
NCBI GenInfo Identifier:460018296
NCBI Gene ID:5867
NCBI Accession:P20338.3
UniProt Secondary Accession:P20338,Q5T7P7, Q9BQ44,
UniProt Related Accession:P20338
Molecular Weight:213
NCBI Full Name:Ras-related protein Rab-4A
NCBI Synonym Full Names:RAB4A, member RAS oncogene family
NCBI Official Symbol:RAB4A  
NCBI Official Synonym Symbols:RAB4; HRES1; HRES-1; HRES-1/RAB4  
NCBI Protein Information:ras-related protein Rab-4A; HTLV-1 related endogenous sequence
UniProt Protein Name:Ras-related protein Rab-4A
Protein Family:Ras-related protein
UniProt Gene Name:RAB4A  
UniProt Entry Name:RAB4A_HUMAN
Anti-RAB4A Antibody (CAB3979)Western blot - RAB4A Rabbit mAb (CAB3979)
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