Cell Biology Antibodies 13
Anti-RAB3GAP2 Antibody (CAB17669)
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- SKU:
- CAB17669
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RAB3GAP2 Antibody |
| Antibody SKU: | CAB17669 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAB3GAP2 (NP_036546.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Rat spleen, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAB3GAP2 (NP_036546.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MACS IVQF CYFQ DLQA ARDF LFPH LREE ILSG ALRR DPSK STDW EDDG WGAW EENE PQEP EEEG NTCK TQKT SWLQ DCVL SLSP TNDL MVIA REQK AVFL VPKW KYSD KGKE EMQF AVGW SGSL NVEE GECV TSAL CIPL ASQK RSST GRPD WTCI VVGF TSGY VRFY TENG VLLL AQLL NEDP VLQL KCRT YEIP RHPG |
| Gene ID: | 25782 |
| Uniprot: | Q9H2M9 |
| Cellular Location: | |
| Calculated MW: | 23kDa/155kDa |
| Observed MW: | 156kDa |
 | Western blot - RAB3GAP2 Polyclonal Antibody (CAB17669) |
| Synonyms: | RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150, RAB3GAP2 |
| Background: | The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009] |
| UniProt Protein Function: | RAB3GAP2: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. Defects in RAB3GAP2 are the cause of Martsolf syndrome (MARTS). Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive. Defects in RAB3GAP2 are the cause of Warburg micro syndrome type 2 (WARBM2). WARBM2 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP regulatory subunit family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rab Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; endoplasmic reticulum membrane; plasma membrane; protein complex Molecular Function:enzyme activator activity; enzyme regulator activity; protein heterodimerization activity; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity Biological Process: intracellular protein transport; regulation of GTPase activity Disease: Martsolf Syndrome; Warburg Micro Syndrome 2 |
| NCBI Summary: | The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9H2M9 |
| NCBI GenInfo Identifier: | 62511132 |
| NCBI Gene ID: | 25782 |
| NCBI Accession: | Q9H2M9.1 |
| UniProt Secondary Accession: | Q9H2M9,O75872, Q9HAB0, Q9UFJ7, Q9UQ15, A6H8V0, |
| UniProt Related Accession: | Q9H2M9 |
| Molecular Weight: | 23,361 Da |
| NCBI Full Name: | Rab3 GTPase-activating protein non-catalytic subunit |
| NCBI Synonym Full Names: | RAB3 GTPase activating non-catalytic protein subunit 2 |
| NCBI Official Symbol: | RAB3GAP2 |
| NCBI Official Synonym Symbols: | p150; SPG69; WARBM2; RAB3GAP150; RAB3-GAP150 |
| NCBI Protein Information: | rab3 GTPase-activating protein non-catalytic subunit |
| UniProt Protein Name: | Rab3 GTPase-activating protein non-catalytic subunit |
| UniProt Synonym Protein Names: | RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit |
| Protein Family: | Rab3 GTPase-activating protein |
| UniProt Gene Name: | RAB3GAP2 |
| UniProt Entry Name: | RBGPR_HUMAN |
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