Cell Biology Antibodies 15

Anti-RAB3GAP1 Antibody (CAB18587)

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SKU:
CAB18587
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RAB3GAP1 Antibody
Antibody SKU:CAB18587
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RAB3GAP1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, Jurkat, Mouse lung, Mouse brain, Rat brain
Immunogen:Recombinant protein of human RAB3GAP1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:22930
Uniprot:Q15042
Cellular Location:
Calculated MW:
Observed MW:130kDa
Anti-RAB3GAP1 Antibody (CAB18587)Western blot - RAB3GAP1 Rabbit pAb (CAB18587)
Synonyms:P130, RAB3GAP, RAB3GAP130, WARBM1, RAB3GAP1
Background:
UniProt Protein Function:RAB3GAP1: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1). A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP catalytic subunit family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q21.3

Cellular Component: protein complex; cytoplasm

Molecular Function:Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding

Biological Process: regulation of GTPase activity; hypothalamus development; camera-type eye development; brain development; regulation of short-term neuronal synaptic plasticity; regulation of excitatory postsynaptic membrane potential

Disease: Warburg Micro Syndrome 1

NCBI Summary:This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
UniProt Code:Q15042
NCBI GenInfo Identifier:55743118
NCBI Gene ID:22930
NCBI Accession:NP_036365.1
UniProt Related Accession:Q15042
Molecular Weight:
NCBI Full Name:rab3 GTPase-activating protein catalytic subunit isoform 2
NCBI Synonym Full Names:RAB3 GTPase activating protein catalytic subunit 1
NCBI Official Symbol:RAB3GAP1  
NCBI Official Synonym Symbols:P130; WARBM1; RAB3GAP; RAB3GAP130  
NCBI Protein Information:rab3 GTPase-activating protein catalytic subunit
UniProt Protein Name:Rab3 GTPase-activating protein catalytic subunit
UniProt Synonym Protein Names:RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130
UniProt Gene Name:RAB3GAP1  
UniProt Entry Name:RB3GP_HUMAN
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