Cell Biology Antibodies 9
Anti-RAB3A Antibody (CAB5379)
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- SKU:
- CAB5379
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RAB3A Antibody |
| Antibody SKU: | CAB5379 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB3A (NP_002857.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB3A (NP_002857.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LMYD ITNE ESFN AVQD WSTQ IKTY SWDN AQVL LVGN KCDM EDER VVSS ERGR QLAD HLGF EFFE ASAK DNIN VKQT FERL VDVI CEKM SESL DTAD PAVT G |
| Gene ID: | 5864 |
| Uniprot: | P20336 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| Calculated MW: | 24kDa |
| Observed MW: | 25kDa |
| Synonyms: | RAB3A |
| Background: |
| UniProt Protein Function: | RAB3A: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: axon; plasma membrane; synaptic vesicle; terminal button Molecular Function:GTPase activity; myosin V binding; protein binding Biological Process: constitutive secretory pathway; glutamate secretion; neurotransmitter secretion; positive regulation of exocytosis; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle exocytosis |
| UniProt Code: | P20336 |
| NCBI GenInfo Identifier: | 131801 |
| NCBI Gene ID: | 5864 |
| NCBI Accession: | P20336.1 |
| UniProt Secondary Accession: | P20336,Q9NYE1, A8K0J4, |
| UniProt Related Accession: | P20336 |
| Molecular Weight: | 24,984 Da |
| NCBI Full Name: | Ras-related protein Rab-3A |
| NCBI Synonym Full Names: | RAB3A, member RAS oncogene family |
| NCBI Official Symbol: | RAB3A |
| NCBI Protein Information: | ras-related protein Rab-3A |
| UniProt Protein Name: | Ras-related protein Rab-3A |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB3A |
| UniProt Entry Name: | RAB3A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RAB3A antibody (CAB5379) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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