Cell Biology Antibodies 14
Anti-RAB35 Antibody (CAB17091)
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- SKU:
- CAB17091
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RAB35 Antibody |
| Antibody SKU: | CAB17091 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAB35 (NP_006852.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAB35 (NP_006852.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VEIN GEKV KLQI WDTA GQER FRTI TSTY YRGT HGVI VVYD VTSA ESFV NVKR WLHE INQN CDDV CRIL VGNK NDDP ERKV VETE DAYK FAGQ MGIQ LFET S |
| Gene ID: | 11021 |
| Uniprot: | Q15286 |
| Cellular Location: | |
| Calculated MW: | 17kDa/23kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RAB35, H-ray, RAB1C, RAY |
| Background: |
| UniProt Protein Function: | RAB35: In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. Interacts with DENND1A and DENND1B in a nucleotide- dependent manner. The low binding to DENND1C is nucleotide- independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell projection membrane; clathrin-coated endocytic vesicle; coated pit; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; intercellular bridge; plasma membrane Molecular Function:GDP binding; GTP binding; GTPase activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding Biological Process: antigen processing and presentation; cytokinesis; endocytic recycling; endosome transport; ER to Golgi vesicle-mediated transport; neurite development; plasma membrane to endosome transport; protein localization |
| UniProt Code: | Q15286 |
| NCBI GenInfo Identifier: | 3024525 |
| NCBI Gene ID: | 11021 |
| NCBI Accession: | Q15286.1 |
| UniProt Secondary Accession: | Q15286,B2R6E0, B4E390, |
| UniProt Related Accession: | Q15286 |
| Molecular Weight: | 17,058 Da |
| NCBI Full Name: | Ras-related protein Rab-35 |
| NCBI Synonym Full Names: | RAB35, member RAS oncogene family |
| NCBI Official Symbol: | RAB35 |
| NCBI Official Synonym Symbols: | RAY; H-ray; RAB1C |
| NCBI Protein Information: | ras-related protein Rab-35 |
| UniProt Protein Name: | Ras-related protein Rab-35 |
| UniProt Synonym Protein Names: | GTP-binding protein RAY; Ras-related protein Rab-1C |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB35 |
| UniProt Entry Name: | RAB35_HUMAN |
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