Description
| Antibody Name: | Anti-RAB2A Antibody |
| Antibody SKU: | CAB11634 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human RAB2A (NP_002856.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HeLa, HT-29, A-549, Mouse lung, Mouse testis, Rat brian |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human RAB2A (NP_002856.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAYA YLFK YIII GDTG VGKS CLLL QFTD KRFQ PVHD LTIG VEFG ARMI TIDG KQIK LQIW DTAG QESF RSIT RSYY RGAA GALL VYDI TRRD TFNH LTTW LEDA RQHS NSNM VIML IGNK SDLE SRRE VKKE EGEA FARE HGLI FMET SAKT ASNV EEAF INTA KEIY EKIQ EGVF DINN EANG IKIG PQHA ATNA THAG NQGG QQAG GGCC |
| Gene ID: | 5862 |
| Uniprot: | P61019 |
| Cellular Location: | Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Lipid-anchor, Melanosome |
| Calculated MW: | 20kDa/23kDa |
| Observed MW: | 24kDa |
| Synonyms: | RAB2A, LHX, RAB2 |
| Background: | The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Rab2: Required for protein transport from the endoplasmic reticulum to the Golgi complex. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 8q12.1-q12.2 Cellular Component: cytosol; Golgi apparatus; Golgi membrane; lysosomal membrane; nucleus Molecular Function:GDP binding; GTP binding; GTPase activity; protein binding Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis |
| NCBI Summary: | The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P61019 |
| NCBI GenInfo Identifier: | 46577636 |
| NCBI Gene ID: | 5862 |
| NCBI Accession: | P61019.1 |
| UniProt Secondary Accession: | P61019,P08886, B2R5W8, B4DMQ5, |
| UniProt Related Accession: | P61019 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Ras-related protein Rab-2A |
| NCBI Synonym Full Names: | RAB2A, member RAS oncogene family |
| NCBI Official Symbol: | RAB2A |
| NCBI Official Synonym Symbols: | LHX; RAB2 |
| NCBI Protein Information: | ras-related protein Rab-2A |
| UniProt Protein Name: | Ras-related protein Rab-2A |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB2A |
 | Western blot analysis of extracts of various cell lines, using RAB2A antibody (CAB11634) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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