Name: Anti-RAB23 Antibody (CAB7979)
Brand: Cell Biology Antibodies 11
SKU: CAB7979
Availability: OutOfStock

Antibody Name:	RAB23 Rabbit Polyclonal Antibody
Antibody SKU:	CAB7979
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_057361.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, Mouse testis, Mouse brain, Mouse kidney, Mouse lung, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_057361.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MLEE DMEV AIKM VVVG NGAV GKSS MIQR YCKG IFTK DYKK TIGV DFLE RQIQ VNDE DVRL MLWD TAGQ EEFD AITK AYYR GAQA CVLV FSTT DRES FEAV SSWR EKVV AEVG DIPT VLVQ NKID LLDD SCIK NEEA EALA KRLK LRFY RTSV KEDL NVNE VFKY LAEK YLQK LKQQ IAED PELT HSSS NKIG VFNT SGGS HSGQ NSGT LNGG DVIN LRPN KQRT KKNR NPFS SCSI P
Gene ID:	51715
Uniprot:	Q9ULC3
Cellular Location:	Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endosome membrane, Lipid-anchor, autophagosome, phagosome, phagosome membrane
Calculated MW:	26kDa
Observed MW:	27kDa

Synonyms:

RAB23, HSPC137

Background:

This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	RAB23: Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2). A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Belongs to the small GTPase superfamily. Rab family.
UniProt Protein Details:	Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 6p11 Cellular Component: phagocytic vesicle membrane; cytoplasm; plasma membrane; endosome membrane; autophagic vacuole; phagocytic vesicle Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding Biological Process: negative regulation of proteolysis; protein transport; spinal cord dorsal/ventral patterning; cellular defense response; cilium biogenesis; embryonic digit morphogenesis; Rab protein signal transduction; negative regulation of transcription factor import into nucleus; autophagic vacuole formation; regulation of smoothened signaling pathway Disease: Carpenter Syndrome 1
NCBI Summary:	This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:	Q9ULC3
NCBI GenInfo Identifier:	523425714
NCBI Gene ID:	51715
NCBI Accession:	NP_001265595.1
UniProt Secondary Accession:	Q9ULC3,Q68DJ6, Q8NI06, Q9P023, B2R9I5,
UniProt Related Accession:	Q9ULC3
Molecular Weight:	26,659 Da
NCBI Full Name:	ras-related protein Rab-23
NCBI Synonym Full Names:	RAB23, member RAS oncogene family
NCBI Official Symbol:	RAB23
NCBI Official Synonym Symbols:	HSPC137
NCBI Protein Information:	ras-related protein Rab-23; RAB family small GTP binding protein RAB 23
UniProt Protein Name:	Ras-related protein Rab-23
Protein Family:	Ras-related protein
UniProt Gene Name:	RAB23
UniProt Entry Name:	RAB23_HUMAN

Anti-RAB23 Polyclonal Antibody (CAB7979)

Western blot analysis of extracts of various cell lines, using RAB23 antibody (CAB7979) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

RAB23 Antibody (PACO11640)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)