Cell Biology Antibodies 8

Anti-RAB18 Antibody (CAB2812)

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SKU:
CAB2812
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RAB18 Antibody
Antibody SKU:CAB2812
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RAB18 (NP_067075.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, A375, 293T, MCF7, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RAB18 (NP_067075.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDED VLTT LKIL IIGE SGVG KSSL LLRF TDDT FDPE LAAT IGVD FKVK TISV DGNK AKLA IWDT AGQE RFRT LTPS YYRG AQGV ILVY DVTR RDTF VKLD NWLN ELET YCTR NDIV NMLV GNKI DKEN REVD RNEG LKFA RKHS MLFI EASA KTCD GVQC AFEE LVEK IIQT PGLW ESEN QNKG VKLS HREE GQGG GACG GYCS VL
Gene ID:22931
Uniprot:Q9NP72
Cellular Location:Cell membrane, Cytoplasmic side, Lipid-anchor
Calculated MW:15kDa/22kDa/26kDa
Observed MW:23kDa
Synonyms:RAB18, RAB18LI1, WARBM3
Background:The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:RAB18: a small G protein that plays a role in apical endocytosis/recycling. May be involved in transport between the plasma membrane and early endosomes.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: Golgi apparatus; plasma membrane; intracellular

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: intracellular protein transport; eye development; metabolic process; small GTPase mediated signal transduction; brain development; Rab protein signal transduction

Disease: Warburg Micro Syndrome 3

NCBI Summary:The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q9NP72
NCBI GenInfo Identifier:12230528
NCBI Gene ID:22931
NCBI Accession:Q9NP72.1
UniProt Secondary Accession:Q9NP72,Q53FX8, Q56UN9, Q6FIH1, B3KMC7, B7Z333, D3DRW1
UniProt Related Accession:Q9NP72
Molecular Weight:206
NCBI Full Name:Ras-related protein Rab-18
NCBI Synonym Full Names:RAB18, member RAS oncogene family
NCBI Official Symbol:RAB18  
NCBI Official Synonym Symbols:WARBM3; RAB18LI1  
NCBI Protein Information:ras-related protein Rab-18; RAB18 small GTPase
UniProt Protein Name:Ras-related protein Rab-18
Protein Family:Ras-related protein
UniProt Gene Name:RAB18  
UniProt Entry Name:RAB18_HUMAN
Anti-RAB18 Antibody (CAB2812)Western blot analysis of extracts of various cell lines, using RAB18 antibody (CAB2812) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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