Immunology Antibodies 2

Anti-RAB11FIP4 Antibody (CAB15914)

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SKU:
CAB15914
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-RAB11FIP4 Antibody
Antibody SKU:CAB15914
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 338-637 of human RAB11FIP4 (NP_116321.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 338-637 of human RAB11FIP4 (NP_116321.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NDIT EKVS FLEK KVTE LEND SLTN GDLK SKLK QENT QLVH RVHE LEEM VKDQ ETTA EQAL EEEA RRHR EAYG KLER EKAT EVEL LNAR VQQL EEEN TELR TTVT RLKS QTEK LDEE RQRM SDRL EDTS LRLK DEMD LYKR MMDK LRQN RLEF QKER EATQ ELIE DLRK ELEH LQMY KLDC ERPG RGRS ASSG LGEF NARA REVE LEHE VKRL KQEN YKLR DQND DLNG QILS LSLY EAKN LFAA QTKA QSLA AEID TASR DELM EALK EQEE INFR LRQY MDKI ILAI LDHN PSIL EIKH
Gene ID:84440
Uniprot:Q86YS3
Cellular Location:Cleavage furrow, Cytoplasmic vesicle, Midbody, Peripheral membrane protein, Recycling endosome membrane
Calculated MW:60kDa/71kDa
Observed MW:72kDa
Synonyms:RAB11FIP4, FIP4-Rab11, RAB11-FIP4
Background:The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma.
UniProt Protein Function:Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
NCBI Summary:The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
UniProt Code:Q86YS3
NCBI GenInfo Identifier:756140942
NCBI Gene ID:84440
NCBI Accession:NP_001290471.2
UniProt Secondary Accession:Q86YS3,Q52LI1, Q8N829, Q8NDT7, Q969D8,
UniProt Related Accession:Q86YS3
Molecular Weight:72kDa
NCBI Full Name:rab11 family-interacting protein 4 isoform 2
NCBI Synonym Full Names:RAB11 family interacting protein 4
NCBI Official Symbol:RAB11FIP4  
NCBI Official Synonym Symbols:FIP4-Rab11; RAB11-FIP4  
NCBI Protein Information:rab11 family-interacting protein 4
UniProt Protein Name:Rab11 family-interacting protein 4
UniProt Synonym Protein Names:Arfophilin-2
Protein Family:Rab11 family-interacting protein
UniProt Gene Name:RAB11FIP4  
Anti-RAB11FIP4 Antibody (CAB15914)Western blot analysis of extracts of U-87MG cells, using RAB11FIP4 antibody (CAB15914) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s.
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