Cell Biology Antibodies 10
Anti-QPCT Antibody (CAB6711)
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- SKU:
- CAB6711
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-QPCT Antibody |
| Antibody SKU: | CAB6711 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGG RHRR VVGT LHLL LLVA ALPW ASRG VSPS ASAW PEEK NYHQ PAIL NSSA LRQI AEGT SISE MWQN DLQP LLIE RYPG SPGS YAAR QHIM QRIQ RLQA DWVL EIDT FLSQ TPYG YRSF SNII STLN PTAK RHLV LACH YDSK YFSH WNNR VFVG ATDS AVPC AMML ELAR ALDK KLLS LKTV SDSK PDLS LQLI FFDG EEAF LHWS PQDS LYGS RHLA AKMA STPH PPGA RGTS QLHG MDLL VLLD LIGA PNPT FPNF FPNS ARWF ERLQ AIEH ELHE LGLL KDHS LEGR YFQN YSYG GVIQ DDHI PFLR RGVP VLHL IPSP FPEV WHTM DDNE ENLD ESTI DNLN KILQ VFVL EYLH L |
| Gene ID: | 25797 |
| Uniprot: | Q16769 |
| Cellular Location: | Secreted |
| Calculated MW: | 35kDa/40kDa |
| Observed MW: | 41kDa |
| Synonyms: | QPCT, GCT, QC, sQC |
| Background: | This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. |
| UniProt Protein Function: | QPCT: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.2.5; Transferase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p22.2 Molecular Function:glutaminyl-peptide cyclotransferase activity; zinc ion binding Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; protein modification process |
| NCBI Summary: | This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16769 |
| NCBI GenInfo Identifier: | 2498824 |
| NCBI Gene ID: | 25797 |
| NCBI Accession: | Q16769.1 |
| UniProt Secondary Accession: | Q16769,Q16770, Q3KRG6, Q53TR4, |
| UniProt Related Accession: | Q16769 |
| Molecular Weight: | 361 |
| NCBI Full Name: | Glutaminyl-peptide cyclotransferase |
| NCBI Synonym Full Names: | glutaminyl-peptide cyclotransferase |
| NCBI Official Symbol: | QPCT |
| NCBI Official Synonym Symbols: | QC; GCT; sQC |
| NCBI Protein Information: | glutaminyl-peptide cyclotransferase; EC; glutamyl cyclase; glutaminyl cyclase; glutaminyl-tRNA cyclotransferase |
| UniProt Protein Name: | Glutaminyl-peptide cyclotransferase |
| UniProt Synonym Protein Names: | Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC |
| UniProt Gene Name: | QPCT |
| UniProt Entry Name: | QPCT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using QPCT antibody (CAB6711) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
 | Immunofluorescence analysis of MCF-7 cells using QPCT antibody (CAB6711). Blue: DAPI for nuclear staining. |
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