Immunology Antibodies 3
Anti-Pyrin Antibody (CAB9599)
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- SKU:
- CAB9599
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Pyrin Antibody |
| Antibody SKU: | CAB9599 |
| Antibody Size: | 20uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human MEFV |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic Peptide of human MEFV |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4210 |
| Uniprot: | O15553 |
| Cellular Location: | Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, autophagosome, cytoskeleton, lamellipodium, ruffle |
| Calculated MW: | 50kDa/64kDa/86kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MEFV, FMF, MEF, TRIM20, pyrin |
| Background: | This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. |
| UniProt Protein Function: | pyrin: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF). ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence. Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF). ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: autophagic vacuole; cytoplasm; cytoplasmic vesicle; cytosol; lamellipodium; microtubule; microtubule associated complex; nucleus; ruffle Molecular Function:actin binding; protein binding; zinc ion binding Biological Process: inflammatory response; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; positive regulation of autophagy Disease: Familial Mediterranean Fever; Familial Mediterranean Fever, Autosomal Dominant |
| NCBI Summary: | This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15553 |
| NCBI GenInfo Identifier: | 4557743 |
| NCBI Gene ID: | 4210 |
| NCBI Accession: | NP_000234.1 |
| UniProt Secondary Accession: | O15553,Q3MJ84, Q96PN4, Q96PN5, D3DUC0, F5H0Q3, |
| UniProt Related Accession: | O15553 |
| Molecular Weight: | 50,837 Da |
| NCBI Full Name: | pyrin isoform 1 |
| NCBI Synonym Full Names: | Mediterranean fever |
| NCBI Official Symbol: | MEFV |
| NCBI Official Synonym Symbols: | FMF; MEF; TRIM20 |
| NCBI Protein Information: | pyrin |
| UniProt Protein Name: | Pyrin |
| UniProt Synonym Protein Names: | Marenostrin |
| Protein Family: | Pyrin |
| UniProt Gene Name: | MEFV |
| UniProt Entry Name: | MEFV_HUMAN |
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