Immunology Antibodies 1

Anti-PXK Antibody (CAB15458)

(No reviews yet) Write a Review
SKU:
CAB15458
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PXK Antibody
Antibody SKU:CAB15458
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PXK (NP_060241.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, U-251MG, Jurkat, Mouse spleen, Mouse lung, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PXK (NP_060241.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAFM EKPP AGKV LLDD TVPL TAAI EASQ SLQS HTEY IIRV QRGI SVEN SWQI VRRY SDFD LLNN SLQI AGLS LPLP PKKL IGNM DREF IAER QKGL QNYL NVIT TNHI LSNC ELVK KFLD PNNY SANY TEIA LQQV SMFF RSEP KWEV VEPL KDIG WRIR KKYF LMKI KNQP KERL VLSW ADLG PDKY LSDK DFQC LIKL
Gene ID:54899
Uniprot:Q7Z7A4
Cellular Location:Cell membrane, Cytoplasm, Peripheral membrane protein
Calculated MW:38kDa/49kDa/55kDa/58kDa/60kDa/62kDa/64kDa
Observed MW:80kDa
Synonyms:PXK, MONAKA, SLOB, MONaKA
Background:This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Slob: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Belongs to the protein kinase superfamily. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; Slob family

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: cytoplasm; plasma membrane; microtubule organizing center; nucleus

Molecular Function:protein C-terminus binding; nucleotide binding; actin binding; ATP binding; phosphoinositide binding; protein kinase activity

Biological Process: regulation of synaptic transmission; inflammatory response; protein amino acid phosphorylation; negative regulation of ion transport; negative regulation of ATPase activity

NCBI Summary:PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008]
UniProt Code:Q7Z7A4
NCBI GenInfo Identifier:31543452
NCBI Gene ID:54899
NCBI Accession:NP_060241.2
UniProt Secondary Accession:Q7Z7A4,Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3 Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8,
UniProt Related Accession:Q7Z7A4
Molecular Weight:64,950 Da
NCBI Full Name:PX domain-containing protein kinase-like protein
NCBI Synonym Full Names:PX domain containing serine/threonine kinase
NCBI Official Symbol:PXK  
NCBI Official Synonym Symbols:MONaKA  
NCBI Protein Information:PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; modulator of Na,K-ATPase long form
UniProt Protein Name:PX domain-containing protein kinase-like protein
UniProt Synonym Protein Names:Modulator of Na,K-ATPase
Protein Family:PX domain-containing protein kinase-like protein
UniProt Gene Name:PXK  
UniProt Entry Name:PXK_HUMAN
Anti-PXK Antibody (CAB15458)Western blot analysis of extracts of various cell lines, using PXK antibody (CAB15458) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
View AllClose

0 Reviews

View AllClose

Related Products