Cell Biology Antibodies 6
Anti-PVRL4 Antibody (CAB16149)
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- SKU:
- CAB16149
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PVRL4 Antibody |
| Antibody SKU: | CAB16149 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-510 of human PVRL4 (NP_112178.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-510 of human PVRL4 (NP_112178.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRY HRRK AQQM TQKY EEEL TLTR ENSI RRLH SHHT DPRS QPEE SVGL RAEG HPDS LKDN SSCS VMSE EPEG RSYS TLTT VREI ETQT ELLS PGSG RAEE EEDQ DEGI KQAM NHFV QENG TLRA KPTG NGIY INGR GHLV |
| Gene ID: | 81607 |
| Uniprot: | Q96NY8 |
| Cellular Location: | Cell junction, Cell membrane, Secreted, Single-pass type I membrane protein, adherens junction |
| Calculated MW: | 24kDa/55kDa |
| Observed MW: | 55kDa |
| Synonyms: | NECTIN4, EDSS1, LNIR, PRR4, PVRL4, nectin-4 |
| Background: | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. |
| UniProt Protein Function: | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. |
| NCBI Summary: | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q96NY8 |
| NCBI GenInfo Identifier: | 74761016 |
| NCBI Gene ID: | 81607 |
| NCBI Accession: | Q96NY8.1 |
| UniProt Secondary Accession: | Q96NY8,Q96K15, B4DQW3, |
| UniProt Related Accession: | Q96NY8 |
| Molecular Weight: | 24,341 Da |
| NCBI Full Name: | Nectin-4 |
| NCBI Synonym Full Names: | nectin cell adhesion molecule 4 |
| NCBI Official Symbol: | NECTIN4 |
| NCBI Official Synonym Symbols: | LNIR; PRR4; EDSS1; PVRL4; nectin-4 |
| NCBI Protein Information: | nectin-4 |
| UniProt Protein Name: | Nectin-4 |
| UniProt Synonym Protein Names: | Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4 |
| UniProt Gene Name: | NECTIN4 |
| UniProt Entry Name: | NECT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PVRL4 antibody (CAB16149) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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