Cell Biology Antibodies 15
Anti-PVRL3 Antibody (CAB4597)
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- SKU:
- CAB4597
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NECTIN3
- Synonyms:
- CD113
- Synonyms:
- CDW113
- Synonyms:
- PPR3
- Synonyms:
- PRR3
- Synonyms:
- PVRL3
- Synonyms:
- PVRR3
- Research Area:
- Cell Biology
Description
| Product Name: | PVRL3 Rabbit pAb |
| Product Code: | CAB4597 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NECTIN3, CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3, nectin-3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 127-366 of human PVRL3 (NP_001230215.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 127-366 of human PVRL3 (NP_001230215.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLND ATIT LHNI GFSD SGKY ICKA VTFP LGNA QSST TVTV LVEP TVSL IKGP DSLI DGGN ETVA AICI AATG KPVA HIDW EGDL GEME STTT SFPN ETAT IISQ YKLF PTRF ARGR RITC VVKH PALE KDIR YSFI LDIQ YAPE VSVT GYDG NWFV GRKG VNLK CNAD ANPP PFKS VWSR LDGQ WPDG LLAS DNTL HFVH PLTF NYSG VYIC KVTN SLGQ RSDQ KVIY ISAY NSVA SLNC |
| Gene ID: | 25945 |
| Uniprot: | Q9NQS3 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 39kDa/54kDa/61kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | PVRL3: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 3q13 Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane Molecular Function:cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion |
| NCBI Summary: | This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9NQS3 |
| NCBI GenInfo Identifier: | 74762752 |
| NCBI Gene ID: | 25945 |
| NCBI Accession: | Q9NQS3.1 |
| UniProt Secondary Accession: | Q9NQS3,Q6NVZ3, Q8NC05, Q8WVU4, Q9BVA9, Q9Y412, E9PFR0 |
| UniProt Related Accession: | Q9NQS3 |
| Molecular Weight: | 54,375 Da |
| NCBI Full Name: | Nectin-3 |
| NCBI Synonym Full Names: | nectin cell adhesion molecule 3 |
| NCBI Official Symbol: | NECTIN3 |
| NCBI Official Synonym Symbols: | PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3 |
| NCBI Protein Information: | nectin-3 |
| UniProt Protein Name: | Nectin-3 |
| UniProt Synonym Protein Names: | CDw113; Nectin cell adhesion molecule 3 |
| UniProt Gene Name: | NECTIN3 |
| UniProt Entry Name: | NECT3_HUMAN |
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